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2001 Fiscal Year Final Research Report Summary

Development of high-sensitive synchrotron x-ray micro CT

Research Project

Project/Area Number 12307018
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity ot Tsukuba

Principal Investigator

ITAI Yuji  University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (30010268)

Co-Investigator(Kenkyū-buntansha) AKATSUKA Takao  Yamagata University, Faculty of Engineering, Professor, 工学部, 教授 (80091875)
TAKEDA Tohoru  University of Tsukuba, Institute of Clinical Medicine, Assistant Professor, 臨床医学系, 講師 (10197311)
Project Period (FY) 2000 – 2001
KeywordsFluorescent x-ray / Computed tomography / Specific element / Diagnostic radiology / Micro imaging / Synchrotron radiation / Functional imaging
Research Abstract

Fluorescent x-ray technique is used to evaluate very low contents of specific elements in the order of picograms, however the measurement must be performed in the surface of object. Then for biological sample, the specimen is required to be cut into thin slices and scanned with a beam perpendicular to its surface. Fluorescent x-ray computed tomography (FXCT) have being developed to reveal the distribution of inner element of object without specific preparation. Especially by positioning the x-ray detector at 90°to the beam, the linear polarization of synchrotron x-rays (SR) helps to significantly reduce the Compton scattering overlapping the Kcc line and thus improving the minimal detectability of elements. Using a Ge detector with high efficiency and high count-rate capability, FXCT was implemented with high spatial resolution in the order of tens of micrometers.
FXCT was applied to depict the cross sectional distribution of iodine in the thyroid gland, in vitro, at the spatial resolution of 0.1mm x 0.1 mm with 0.1-mm slice thickness or of 0.025 mm x 0.025 mm with 0.025 mm slice thickness. FXCT with synchrotron radiation could clearly visualize the 0.005 mg/ml iodine solution in the 10-mm diameter 3-hole phantom at 0.1 x 0.1 mmz spatial resolution with 0.1mm slice thickness. Observation of the 0.005 mg/ml iodine solution indicated that the excited iodine content in the measured voxel is about 5 pg. In the thyroid cancer, FXCT revealed that a part of cancer had high content of iodine, whereas another part had low content of iodine. It varied wide ranges from 0.09 mg/g to 0.005 mg/g. Experimental ring (AR) for FXCT was improved this spring, so high spatial resolution images with 0.005mm is planned to obtain using this new system. , '

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Tohoru Takeda: "Newtypes of x-ray computed tomography with synchrotron radiation : fluorescent x-ray CT and phase-contrast x-ray CT with interferometer"Cellular & Molecular Biology. 46. 1077-1088 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohoru Takeda: "Biomedical imaging by fluorescent x-ray micro-computed tomography"JSBB. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohoru Takeda: "Medical imaging by Fluorescent x-ray CT : its preliminary clinical evaluation"SPIE. 4503. 299-309 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohoru Takeda: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research. A467-468. 1318-1321 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Quanwen Yu: "Preliminary experiment of fluerescent x-ray computed tomography to detect dual agents for biomedical study"J. Synchrotron Radiation. 8. 1030-1034 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsutomu Zeniya: "Integrated image presentation of transmission and fluorescent x-ray CT using synchrotron radiation"Nuclear Instruments and Method in Physics Research. A467-468. 1326-1328 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohoru Takeda: "Progress in Pathology Volume 5"Greenwich Medical Media Ltd. UK. 194 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeda T, Momose A, Yu Q, Yuasa T, Dilmanian FA, Akatsuka T, Itai Y: "New types of x-ray computed tomography with synchrotron radiation : fluorescent x-ray CT and phase-contrast x-ray CT with interferometer"Cellular & Molecular Biology. 46. 1077-1088 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeda T, Zeniya T, Wu J, Yu Q, Thet-Thet-Lwin, Tsushiya Y, D. V. Rao, Yuasa T, Yashiro T, Dilmanian FA, Itai Y, Akatsuka T: "Medical imaging by fluorescent x-ray CT: Its preliminary clinical evaluation"SPIE. 4503. 299-309 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeda T, Yu Q, Yashiro T, Zeniya T, Wu J, Hasegawa Y, Thet-Thet-Lwin, Hypdo K, Yuasa T, Dilmanian FA, Akatsuka T, Itai Y: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research A. 467-468. 1318-1321 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zeniya T TakedaT, Yu Q, Hasegawa Y, Hyodo K, Yuasa T, Hiranaka Y, Itai Y, Akatsuka T: "Integrated image presentation of transmission and fluorescent x-ray CT using synchrotron radiation"Nuclear Instruments and Method in Physics Research A. 467-468. 1326-1328 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yu Q, Takeda T, Yuasa T, Hasegawa Y, Jin W, Thet-Thet-Lwin, Hyodo K, Dilmanian FA, Itai Y, Akatsuka T: "Preliminary experiment of fluorescent x-ray computed tomography to detect dual agents for biomedical study"J. Synchrotron Radiation. 8. 1030-1034 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] TakedaT, Momose A, Wu J, Zeniya T, Yu Q,: "Phase-contrast x-ray computed tomography of non-formalin fixed biological objects"Nuclear Instruments and Method in Physics Research A. 467-468. 1322-1325 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeda T, ZeniyaT, Wu J, Thet-Thet-Lwin, Yu Q, Tsuchiya Y, Yashiro T, Yuasa T, D V Rao, Hyodo K, Dilmanian F A, Itai Y, Akatsuka T: "Biomedical imaging by fluorescent x-ray micro-computed tomography"JSBB. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] TakedaT, Itai Y: "X-ray micro-computed tomography using synchrotron radiation"Editedby Kirkham N, Lemoine NR, Progress in Pathology p81-102, 2001UK.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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