2001 Fiscal Year Final Research Report Summary
Development of Biomaterials which Induce Tissue and Organ
| Project/Area Number |
12307047
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | School of Dentistry Aichi-gakuin university |
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Principal Investigator |
KAWAI Tatsushi Dental Material Science, School of Dentistry Aichi-gakuin university, Professor, 歯学部・歯科理工学, 教授 (60167351)
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| Co-Investigator(Kenkyū-buntansha) |
TSURUTA Syouzou Dental Material Science, School of Dentistry Aichi-gakuin university, Assistant Professor, 歯学部・歯科理工学, 講師 (40183488)
TAKAHASHI Yoshifumi Dental Material Science, School of Dentistry Aichi-gakuin university, Associate Professor, 歯学部・歯科理工学, 助教授 (00090142)
FUKUI Hisao Dental Material Science, School of Dentistry Aichi-gakuin university, Professor, 歯学部・歯科理工学, 特種基礎研究教授 (50090147)
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| Project Period (FY) |
2000 – 2001
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| Keywords | BMP / Bone morphogenetic protein / scaffold / biomaterial / functional material / implant / osteoinduction |
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| Research Abstract |
It is elucidated that both HAP-BMP composite material, which was used as a frame works, and artificial membrane - BMP composite material induced new bone and cartilage , those are useful as tissue organ inducible biomaterials. However, outer shape of implant, which was constructed with BMP as a framework, should have smooth surface and no sharp edge. Therefore, lubricating the surface of HAP and delete of the sharp edge is remarkably important. It is very hard to induce new bone inside of the inner vacant space of tubules shape of HAP. It demonstrates that not only the BMP is a factor of bone induction but also another unknown factor influence the osteogenesity. VEGF(vascular endothelial growth factor) or some other factors could be a cofactor for the new bone formation.
It is considered that this information contributes largely to the next project. All artificial membrane -BMP composite showed new bone formation, and those are applicable for the clinical usage, such as GTR method. When biodegradable membrane is used, induction of new cartilage in vitro was very hard. More basic research work is necessary on this material for the application to clinical usage. There was only one research report for the cartilage induction on the artificial membrane previously. New cartilage formation on acetate membrane was successfully performed in this project. This induction remained only cartilage stage and not progress to osteoinduction but new bone formation could be possible by transplanting this system in vivo. Consequently, two kinds of tissue organ biomaterials, which are HAP-BMP composite and artificial membrane - BMP composite, are developed through these experiments, and important information for the application of this material for the clinical usage was accumulated.
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Research Products
(13 results)
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[Publications] Izawa, H., Hachiya, Y., Kawai, T., Muramatsu, K., Narita, Y., Ban, S., Yoshizawa, H.: "The Effect of Heat-Treated Human Bone Morphogenetic Protein on Clinical Implantation"Clin Orthop. 390. 252-258 (2001)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kawakami.T., Kawai.T., Kimura, A., Hasegawa, J., Ishiwari, Y., Nagatsuka, H., Nagai, N.: "Characteristics of Bone Morphogenetic Protein induced Chondroid Bone : Histochemical, Immunohistochemical and in situ Hybridization Examinations"J Int Med Res. 29. 480-487 (2001)
Description
「研究成果報告書概要(和文)」より
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[Publications] Murakami, H., Mizuguchi, M., Hattori, M., Ito, Y., Kawai, T., Hasegawa, J.: "Effect of denture cleaner using ozone against methicillin-resistant staphylococcus aureus and E. coli T1 phage"Dental Materials Journal. 21(1). 53-60 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Watanabe, T., Ban, S., Ito, T., Tsuruta, S., Kawai, T., Nakamura, H.: "Oriented needle-like apatite and biodegradable copolymer composite membranes"Bioceramics. 15. 191-194 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Izawa, H., Hachiya, Y., Kawai, T., Muramatsu, K., Narita, Y., Ban, S., Yoshizawa, H.: "The Effect of Heat-Treated Human Bone morphogenetic Protein on Clinical Imprantation"Clin Orthop. 390. 252-258 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kawakami, T., Kawai, T., Kimura, Y., Hasegawa. J., Ishiwari, Y., Nagatsuka, H., Nagai, N.: "Characteristics of Bone Morphogenetic Protein-induced Chondroid Bone : Histochemical, Immunohistochemical and in situ Hybridization Examinations"J Int Med Res. 29. 480-487 (2001)
Description
「研究成果報告書概要(欧文)」より
-
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[Publications] Murakami, H., Mizuguchi, M., Hattori, M., Ito, Y., Kawai, T., Hasegawa, J.: "Effect of denture cleaner using ozone against methicillin-resistant staphylococcus aureus and E. coli T1 phage"Dental Materials Journal. 21(1). 53-60 (2002)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Watanabe, T., Ban, S., Ito, T., Tsuruta, S., Kawai, T., Nakamura, H.: "Oriented needle-like apatite and biodegradable copolymer composite membranes"Bioceramics. 15. 191-194 (2002)
Description
「研究成果報告書概要(欧文)」より
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