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2003 Fiscal Year Final Research Report Summary

Search for dynamic neuronal assemblies underlying memory processes for order information

Research Project

Project/Area Number 12410028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SAKURAI Yoshio  Kyoto University, Graduate School of Letters, Professor, 大学院・文学研究科, 教授 (60153962)

Project Period (FY) 2000 – 2003
Keywordsneuron / cell-assembly / temporal information / multi-neurnnal activity / hippocampus / rat
Research Abstract

(1) For rats, we developed behavioral tasks to see memory for duration or order of presented tone stimuli and trained rats to perform both tasks. The rats acquired both tasks in three weeks. We recorded multi-neuronal activity. from their hippocampal formation during the performance of the tasks.
(2) For mice, we developed a behavioral task to see memory for order of presented light stimuli and trained mice to perform the task. Some mice could not fully acquire the task in a long training period and we needed to change parameters of the task to more adequate ones.
(3) We developed new techniques, i.e., electrode, head-amp, microdrive, and spike-sorting system, to record and analyze multi-neuronal activity in behaving animals.
(4) The most remarkable one of the newly developed techniques is a new method to detect precise sub-millisecond interactions among neurons in freely behaving animals. That is an in vivo electrophysiological technique capable of real-time and automatic sorting of extracellular activity of closely neighboring single-neurons to detect their sub-millisecond interactions. The technique uses a combination of independent component analysis (ICA) and newly developed multi-electrodes, dozentrodes.
(5) Up to 10 interacting single-neurons were simultaneously recorded with two dozentrodes implanted in the hippocampal CA1 and CA3 regions and the somatosensory cortex in.the rats.
(6) The technique also could detect dendritic backpropagation of action potentials and electrically coupled cells via gap junctions. These results demonstrate that our method can be employed to investigate extremely precise neuronal interactions, as well as the functions of dendritic compartments that underlie learning and motor control in freely behaving animals.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 櫻井芳雄: "マルチニューロン活動の記録-なぜ・どのようにして"電子情報通信学会誌. 87. 279-284 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 櫻井芳雄: "セル・アセンブリによる神経情報の表現-実験的検証に向けて"蛋白質・核酸・酵素. 49. 463-470 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, S. et al.: "A new approach to spike sorting for multi-neuronal activities recorded with a tetrode-how ICA can be practical"Neuroscience Research. 46. 265-272 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, S. et al.: "Automatic sorting for multi-neuronal activity recorded with tetrodes in the presence of overlapping spikes"Journal of Neurophysiology. 89. 2245-2258 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 櫻井芳雄: "マルチニューロン活動を記録するために"脳の科学. 25. 19-26 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakurai, Y.: "Coding of temporal and pitch information by hippocampal"Neuroscience. 115. 1153-1163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 櫻井芳雄: "考える細胞ニューロン"講談社. 232 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakurai, Y: "Multi-neuronal recordings why and how."J. of the Institute of Electronics, Information and Communication Engineers. 87. 279-284 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurai, Y: "Neuronal coding by cell assemblies."Protein, Nucleic Acid and Enzyme. 49. 463-470 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, S. et al.: "A new approach to spike sorting..."Neuroscience Research. 46. 265-272 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, S. et al.: "Automatic sorting for multi-neuronal.."J.of Neurophysiology. 89. 2245-2258 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurai, Y: "To record multi-neuronal activity."Brain Science. 25. 19-26 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurai, Y: "Coding of temporal and pitch information by..."Neuroscience. 115. 1153-1163 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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