2002 Fiscal Year Final Research Report Summary
Development of New Lewis Acid Catalysts based on Late-Transition Metal Complexes
| Project/Area Number |
12450361
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University (2002)
Toyohashi University of Technology (2000-2001) |
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Principal Investigator |
NISHIYAMA Hisao Nagoya University, Graduate School of Engineering, Professor, 工学研究科, 教授 (40135421)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Lewis Acid / Asymmetric Synthesis / Oxazoline / aqueous system / Rhodium / 1,3-dipolar |
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| Research Abstract |
In order to develop a new class of Lewis acid catalysts, complexes of late-transition metals have been investigated including chiral skeleton on the binding oragnic parts. The new complexes have been characterized by NMR and X-ray analysis. The catalysts have also designed to have some profiles, such as water tolerable and recyclable.
We have developed new type of ligands including chiral oxazoline-pyridine derivatives, bis(oxazolinyl)pyridines, bis(oxazolinyl)phenyl, and bis(oxazolinyl)xantenes, which were derived from optically active beta-aminoalcohols. We have determined structures of several rhodium, ruthenium, platinum, and palladium complexes with oxazoline skeletons by X-ray analysis. Espetially, Phebox-Rh complexes exhibited catalytic activity as Lewis acids to promote Diels-Alder reaction, hetero-Diesl-Alder reaction, and aldol reactions giving higher enantioselectivities. The catalyst shows the activity in aqueous media.
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Research Products
(2 results)
