2001 Fiscal Year Final Research Report Summary
Study to prepare safe educational bacterial strains for medical education
| Project/Area Number |
12470062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Gifu University |
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Principal Investigator |
EZAKI Takayuki Gifu Univ., Microbiology, Professor, 医学部, 教授 (90151977)
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| Co-Investigator(Kenkyū-buntansha) |
KURAZONO Hisaso Okayama Univ., Microbiology, Professor, 医学部, 教授 (90186487)
LIDA Tetsuya Osaka Univ., Microbiology, Assist. Professor, 微生物病研究所, 助教授 (90221746)
MAKINO Souichi Obihiro Chikusan Univ., Microbiology, Assist. Professor, 畜産学部, 助教授 (30181621)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Lebel 2 / Lebel 3 / Education / Biosafty / Pathogen / Medicine / 感染症 |
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| Research Abstract |
Through this study, we constructed safe bacterial strains for educational purpose. Because level 3 and potent toxigenic level 2 bacterial pathogens are requested to use for medical education. However, most of university does not have appropriate facility for education. Class 3 facility is not prepared for student teaching room at most of medical universities. We collected information to decrease the level of pathogenicity for level 3 pathogens and selected candidate strains for educational purpose.
Most candidate strains are knocked out their pathogenic factors. We propose to decrease biosafty level of these knocked out strains ofpathogenic factors. These strains should be widely distributed among researchers to evaluate their safety level in future
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[Publications] Zhao,L.1, Ezaki,T., Li,Z.Y., Kawamura,Y., Hirose,K., Watanabe: "Vi-suppressed wild strain Salmonella typhi cultured in high osmolarity is hyperinvasive to epithelial cells and destructive of Peyer's patches"Microbio. Immunol. 45. 149-158 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] lida,T., Hattori,A., Tagomori,K., Nasu,H., Naim,R, Honda,T.: "Filamentous phage associated with recent pandemic strains of Vibrio parahaemolyticus"Emerg Infect Dis.. 7 ( 3 ). 477-478 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Nakano,M., Yamamoto,S., Terai,A., Ogawa,O., Makino,SI., Hayashi,H., Nair,GB., Kurazono,H.: "Structural and sequence diversity of the pathogenicity island of uropathogenic Escherichia coli which encodes the USP protein"FEMS Microbiol Lett. 205 ( 1 ). 71-76 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Yamamoto,S., Nakano,M., Terai,K., Nakata,K., Nair GB., Kurazono,H., Ogawa,O.: "The presence of the virulence island contains usp gene in uropathogenic Escherichia coli is associated with tract infection in an experimental mouse"J. Urol. 165. 1347-1351 (2001)
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「研究成果報告書概要(欧文)」より
