2002 Fiscal Year Final Research Report Summary
Recognition of Lipopolysaccharide by The Toll Receptor Complex
| Project/Area Number |
12470078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo (2001-2002)
佐賀医科大学 (2000) |
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Principal Investigator |
MIYAKE Kensuke The Institute of Medical Science, professor, 医科学研究所, 教授 (60229812)
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| Project Period (FY) |
2000 – 2002
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| Keywords | innate immunity / Toll-like receptor / MD-2 / Lipopolysaccharide / pathogen |
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| Research Abstract |
LPS is a principal component of Gram-negative bacteria that activates the innate immune system, and one of the best-studied microbial products. LPS recognition molecules are MD-2 and Toll-like receptor 4 (TLR4). MD-2 is indispensable for LPS responses, since mice lacking MD-2 do not respond to LPS.
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