2001 Fiscal Year Final Research Report Summary
ANALYSIS OF IMMUNE REGULATION BY ADHESION MOLECULE COMPLEX ON KILLER LYMPHOCYTES
| Project/Area Number |
12470111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | UNIVERSITY OF TSUKUBA |
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Principal Investigator |
SHIBUYA Akira University of Tsukuba, Institute of Basic Medical Sciences, Department of Immunology, Professor, 基礎医学系, 助教授 (80216027)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMA Atsushi University of Tsukuba, Institute of Basic Medical Sciences, Department of Immunology, Assistant Professor, 基礎医学系, 講師 (70244126)
SHIBUYA Kazuko Laboratory for Immune Receptor, RIKEN(RCAI), Research Scientist, 免疫アレルギー科学総合研究センター, 研究員 (00302406)
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| Project Period (FY) |
2000 – 2001
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| Keywords | DNAM-1 / killer lymphocytes / viral infection / cancer / CD155 / CD1112 |
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| Research Abstract |
Cytotoxic lymphocytes play an important role for immune defense against virus-infected cells and cancer. Intercellular adhesion molecule is involved in binding between killer lymphocytes and target cells. We previously identified a novel adhesion molecule DNAM-1 (CD226). Here we have explored the regulatory mechanisms of intercellular binding and signaling mediated by DNAM-1, leading to fundamental understanding for immune defense against virus infection and cancer. Moreover, we have also identified CD155 and CD112 as the DNAM-1 ligands. DNAM-1 binding with its ligands mediates activation signal in cytotoxic Lymphocytes. In addition, we have demonstrated that DNAM-1 also plays an important role for regulation of immune system and thrombosis.
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