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2002 Fiscal Year Final Research Report Summary

Modulation of Inflammatory Process in COPD Airways

Research Project

Project/Area Number 12470132
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

ICHINOSE Masakazu  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (80223105)

Project Period (FY) 2000 – 2002
KeywordsCOPD / nitric oxide / inducible nitric oxide aynthase / peroxynitrite / chronic bronchitis / emphysema / reactive nitrogen / airway inflammation
Research Abstract

Reactive nitrogen species (RNS) including peroxynitrite and nitrogen dioxide, which are formed in the reaction of nitrogen oxide (NO) with superoxide anion and peroxidase-dependent mechanisms, have a potent inflammatory action. Therefore, these molecules may increase and have a role in inflammatory airway diseases. In the present study, we quantified the RNS using immunostaining of nitrotyrosine and inducible NO synthase (iNOS) in airway inflammatory cells obtained by the induced sputum technique as well as the exhaled NO concentration in chronic obstructive pulmonary disease (COPD), asthma and healthy subjets (HS). iNOS immunoreactivity observed in the airway inflammatory cells was significantly and similarly higher in COPD and asthma compared with HS, although the exhaled NO levels were elevated in asthma but not in COPD and HS. The nitrotyrosine immunoreactivity in the inflammatory cells was obvious in COPD and to a lesser extent in asthma but not in HS. There was a significant negative correlation between the percent predicted values of forced expiratory volume in one second and the amount of nitrotyrosine formation in COPD but not in asthma and HS. These results suggest that 1)RNS may be involved in the pathobiology of the airway inflammatory and obstructive process in COPD, 2)NO produced in the airways, presumably via iNOS, seems to be consumed by its reaction with superoxide anion and/or peroxidase-dependent mechanisms.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 小荒井晃他: "INOS depletion completely diminishes reactive nitrogen-species formation after allergic response"European Respiratory Journal. 20. 609-616 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸蒔雅文他: "Comparison of effects of anti-IL3,Il-5 and GM-CSF treatments on Eosinophilopoiesis and airway eosinophilia induced by allergen"Pulmonary Pharmacology & Therapeutics. 15. 161-168 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大類孝他: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax. 57. 561-561 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ohrui, H.Arai, M.Ichinose, T.Matsui, M.Yamaya, H.Sasaki: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax 2002. 57. 561 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Tomaki, L.-L.Zhao, M.Sjostrand, A.Linden, M.Ichinose, J.L.Lotvall: "Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen"Pulm Pharm Ther 2002. 15. 161-168 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Koarai, M.Ichinose, H.Sugiura, M.Tomaki, M.Watanabe, S.Yamagata, Y.Komaki, K.Shirato, T.Hattori: "iNOS depletion completely diminishes reactive nitrogen species formation after allergic response"Eur respir J2002. 20. 609-616 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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