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2001 Fiscal Year Final Research Report Summary

A STUDY OF DEVELOPMENT/REGENERATION PROCESSES OF THE PERIODONTAL NERVES, WITH SPECIAL REFERENCE TO THE ROLE OF NEUROTROPHINS/NEUROTROPHIN RECEPTORS.

Research Project

Project/Area Number 12470382
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

MAEDA Takeyasu  GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES, NIIGATA UNIVERSITY, PROFESSOR, 大学院・医歯学総合研究科, 教授 (40183941)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hitoshi  GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES, NIIGATA UNIVERSITY, ASSISTANT, 大学院・医歯学総合研究科, 助手 (80265165)
KAWANO Yoshiro  GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES, NIIGATA UNIVERSITY, ASSISTANT, 大学院・医歯学総合研究科, 助手 (60303129)
OHSHIMA Hayayo  GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES, NIIGATA UNIVERSITY, PROFESSOR, 大学院・医歯学総合研究科, 教授 (70251824)
Project Period (FY) 2000 – 2001
KeywordsTrkB / BDNF / Ruffini ending / periodontal ligament / terminal Schwann cell / development / regeneration / Imunohistochemistry / histochemistry / PGP9.5
Research Abstract

1. Following injury to the inferior alveolar nerve, the periodontal Ruffini endings can regenerate more rapidly than Ruffini endings in other tissues. During regeneration, terminal Schwann cells associated with the periodontal Ruffini endings migrate into regions where they are never found under normal conditions, and alterations in the expression level of various bioactive substances occurred in both axonal and Schwann cell elements in the periodontal Ruffini endings.
2. Histochemistry for non-specific cholinesterase activity could demonstrate the age-related development of the terminal Schwann cells : the morphology and distribution of the developing terminal Schwann cells becase almost identical to those in adults during postnatal days 15-18. Axons showing PGP9.5-immunoreactivity elongated and expanded and expanded after arrangement of terminal Schwann cells in the alveolus-related part of rat incisor ligament.
3. The heterogeneous distribution of TrkB, a high affinity neurotrophins receptor, was found among individual periodontal Ruffini endings. Some terminal Schwann cells also displayed TrkB-immunoreactivity, confirmed by in situ hybridization histochemistry using a cRNA probe which we prepared.
4. Innervation and terminal morphology in the incisor periodontal ligament were investigated in brain derived neurotrophic factors (BDNF) +/- mice and littermate wild-type mice by immunohistochemistry for PGP 9.5.). BDNF depletion induced the malformation of the Ruffii endings ; which included fewere nerve fibers, less ramifications and fewer terminal buttons as well as ruffled-outlines of the axon terminals, suggesting that BDNF are involved in, the development and maturation of the Ruffini endings in the periodontal ligament.

  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Satoshi Wakisaka: "Morphological and cytochemical characteristic of periodontal Ruffini endings under normal and regenerating processes"Archives of Histology and Cytology. 63・2. 91-113 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田健康: "歯根膜神経終末の形態学的基盤"解剖学雑誌. 75・4. 377-380 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachiko Hayashi: "The development of terminal Schvann cells associated with periodontal Ruffini endings in the rat incisor ligament"Brain Research. 858・1. 167-171 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukako Atsumi: "Immunohitochemical detection of heme oxygenase-2 in the periodontal Ruffini ending of the rat incisor"Brain Research. 855・2. 287-291 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukako Atsumi: "Effects of different types of injury to the inferior alveolar nerve on the behavior of Schwann cells during the regeneration of the periodontal nerve fibers of the rat incisor"Archives of Histology and Cytology. 63・1. 43-54 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukako Atsumi: "Delayed expression of calbindin D28k during regeneration of the periodontal Ruffini endings of the rat incisor following injury to the inferior alveolar nerve"Cells Tissues Organs. 167・4. 285-289 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanako Ochi: "Experimental tooth movement alters the expression of TrkB-like immunoreactivity in the periodontal fibroblasts of rat molars"Orthodontic Waves. 59・6. 393-401 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hitoshi Yamamoto: "Immunocytochemical detection of superoxide dismutases (SODs) in the periodontal Ruffini endings of the rat incisor"Brain Research. 905・1-2. 232-235 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuniyasu Hiroshima: "Temporal and spatial distribution of Fos protein in the parabrachial nucleus nurons during experimental tooth movement of the rat molar"Brain Research. 908・2. 161-173 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yumiko Yamazaki: "Tempotal and spatial distribution of Fos protein in the lumber spinal dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve"Brain Research. 914・1-2. 106-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisao Ajima: "The exact expression of glial fibrillary acidic protein (GPAP) in trigeminal ganglion and dental pulp"Archives of Histology and Cytology. 64・5. 503-511 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Seo: "Optical imaging of excitation propagation evoked by stimulation to the trigeminal caudalis"NeuroReport. 12・18. 3985-3988 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hironobu Suzuki: "Expression of galanin receptor 1 (GALR1) in the rat trigeminal ganglia and molar teeth"Neurosceince Research. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoshi Wakisaka: "Morphological and cytochemical characteristic of periodontal Ruffini endings under normal and regenerating processes"Arch. Histo. Cytol. 63(2). 91-113 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeyas MAEDA: "Morphological basis of Periodontal nerve endings"Acta Anatomica Nipponica. 75(4). 377-380 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sachiko Hayashi: "The development of terminal Schwann cells associated with periodontal Ruffini endings in the rat incisor ligament"Brain Res. 858(1). 167-171 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukako Atsumi: "Immunohistochemical detection of heme oxygenase-2 in the periodontal Ruffini ending of the rat incisor"Brain Res. 855(2). 287-291 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukako Atsumi: "Effects of different types of injury to the inferior alveolar nerve on the behavior of Schwann cells during the regeneration of the periodontal nerve fibers of the rat incisor"Arch. Histol. Cytol.. 63(1). 43-54 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukako Atsumi: "Delayed expression of calbindin D28k during regeneration of the periodontal Ruffini endings of the rat incisor following injury to the inferior alveolar nerve"Cells Tissues Organs. 67(4). 285-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanako Ochi: "Experimental tooth movement alters the expression of TrkB-like immunoreactivity in the periodontal fibroblasts of rat molars"Orthqd. Waves. 59(6). 393-401 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hitoshi Yamamoto: "Immunocytochemical detection of superoxide dismutases (SODs) in the periodontal Ruffini endings of the rat incisor"Brain Res. 905(1-2). 232-235 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuniyasu Hiroshima: "Temporal and spatial distribution of Fos protein in the parabrachial nucleus neurons during experimental tooth movement of the rat molar"Brain Res. 908(2). 161-173 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumiko Yamazaki: "Temporal and spatial distribution of Fos protein in the lumber spinal /dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve"Brain Res. 914(1-2). 106-114 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisao. Ajima: "The exact expression of glial fibrillary acidic protein (GFAP) in trigeminal ganglion and dental pulp"Arch. Histol. Cytol. 64(5). 503-511 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Seo: "Optical imaging of excitation propagation evoked by stimulation to the trigeminal caudalis"NeuroReport. 12(18). 3985-3988 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hironobu Suzuki: "Expression of galanin receptor 1 (GALR1) in the rat trigeminal ganglia and molar teeth"Neurosci. Res. (in press) (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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