2002 Fiscal Year Final Research Report Summary
Action Mechanism of Stress in the Higher Brain Mechanisms and Modulation of Sedation
| Project/Area Number |
12470446
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KAWAHARA Hiroshi Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (10186124)
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| Co-Investigator(Kenkyū-buntansha) |
SHIIBA Shunji Faculty of Dentistry, Instructor, 歯学部, 助手 (20285472)
TANAKA Masatoshi Kurume University School, Professor of Medicine, Faculty of Medicine, 医学部, 教授 (10080954)
NAKANISHI Osamu Faculty of Dentistry, Professor, 歯学部, 教授 (50137345)
SAKAMOTO Eiji Faculty of Dentistry, Instructor, 歯学部, 助手 (00295859)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Stress / Microdialysis / Neuronal Network / Monoamine Neurons / Locus Ceruleus / Prefrontal Cortex / Benzodiazepine / Anxiolytics |
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| Research Abstract |
The stress cognition and the emotional appearance are the higher brain functions formed with complex brain neural network mechanisms. The influence of selective anxiolytics, selective sedatives, and benzogeazepins to these higher brain functions, were examined used with microdiaiysis. The load time of the stress, and these drugs, laboratory animal in no anesthetizing, unrestraint, and the state of the freely moving were examined from the movement of the neurotransmitters in the brain when administering them.
As a result, it was shown that selective anxiolytics, selective sedatives, and benzogeazepins had different actions for the locus coeruleus (LC) - prefrontal cortex (PFC) norepinephrine nerve activity and ventral tegmental area (VTA) - nucleus accumbens (N.Acc.) dopamine nerve activity. Both of the norepinephrine nerve activity in the state of stress and VTA- N.Acc. dopamine nerve activity controlled by benzodiazepines. Selective anxiolytics controlled only the LC-PFC norepinephrine nerve activity. Selective sedatives controlled only the VTA-N. Acc. dopamine nerve activity. Differed the action on the neural network in the brain taking part in the selection of an anxyolytic action and sedative action
Selective anxiolytics and the selective sedatives showed the muscle relax action which differed from benzogeazepin system medicine, and originated in LC and it was shown not to appear. As for selective anxiolytics and selective sedatives have a few effect of the upper airway obstruction and depress breathing . It was thought that there was no muscle relax action which originated in LC as the reason.
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[Publications] Westerink, BHC, Kawahara Y, de Boer P, Geels C, de Vries JB, Wikstrom HV, Van Kalkeren A, Van Vliet, B, Kruse CG, Long, SK: "Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum"European Journal of Pharmacology. 412. 127-138 (2001)
Description
「研究成果報告書概要(欧文)」より
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