2001 Fiscal Year Final Research Report Summary
Construction of New Biological Screening System Using Insects and Search for Biologically Active Substances from Natural Sources
| Project/Area Number |
12470474
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
OSHIMA Yoshiteru Tohoku Univ., Graduate School of Pharm. Sci., Professor, 大学院・薬学研究科, 教授 (00111302)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Haruhisa Tohoku Univ., Graduate School of Pharm. Sci., Instructor, 大学院・薬学研究科, 助手 (90302166)
KURATA Shoichiro Tohoku Univ., Graduate School of Pharm. Sci., Associate Professor, 大学院・薬学研究科, 助教授 (90221944)
TAKAYA Yoshiaki Meijo Univ., Faculty of Pharm. Sci., Associate Professor, 薬学部, 助教授 (80301034)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Innate Immunity / Insect / Screening System / 細胞性粘菌 |
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| Research Abstract |
(1) The immune response in Drosophila and other insects has recently received much interest as a model for innate immune reactions in general because it could lead to the understanding of the immune system of mammalians and the discovery of novel drugs. Thus, we constructed the novel screening system using transgenic Drosophila which is useful to search the compounds affecting the innate immunity.
(2) We investigated the constituents of cellular slime molds to clarify the diversity of their secondary metabolites and to explore biologically active substances that could be useful for development of novel drugs. From their multicellular fruit bodies, we isolated novel α-pyronoids, aromatics, and amino sugar analogues showing a variety of biological activities.
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