2002 Fiscal Year Final Research Report Summary
The phenotypical difference between the Japanese males of the different Y chromosome lineage and their fitness to the modern society.
| Project/Area Number |
12470517
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKAHORI Yutaka The University of Tokushima, Graduate School of Medicine, Professor, 医学研究科, 教授 (10172389)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Takamichi The University of Tokushima, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (80155267)
SHINKA Toshikatsu The University of Tokushima, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (10311820)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Y chromosome / Japanese / Jomon / Yayoi / phenotype |
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| Research Abstract |
The nowadays Japanese consists of two main groups. One group is original Japanese (≒ Jomon people) who resides in the Japanese Islands from 10,000 years or more before. The other group is the immigrant (≒ Yayoi people) who came across the sea mainly via the Korean Peninsula from 3000 years before to the Asuka period. The population of the Japanese Islands increased from 100,000 to 6 million in this period. The rate of population increase was marvelous thinking of natural increase rate in the other population. Therefore, a considerable number of immigrant reached Japan. In the present population, interests are on the ratio and the distribution of these two groups. In 2002, newly Y chromosome pedigrees around the world was introduced by the Y chromosome consortium. This offered us the new aspect to the classification of Japanese males.
My working hypothesis has been that at least a part of the genes on Y chromosome are working on sexual selection of a male. Under the cooperation of students, we investigated various characters of male students and statistically analyzed the data obtained from them. The first-stage impression suggests that the phenotypical difference exist in males of the different Y chromosome lineage. Since the data we collected were too wide in the range and too rough in the quality, the detailed and well organized experimental design is needed to elucidate the phenotypical differences between the different male lineages.
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[Publications] Tomomasa, H., Adachi, Y., Iwabuchi, M., Oshio, S., Umeda, T., Iino, Y., Takano, T., Nakahori, Y.: "Pericentric inversion of the Y chromosome of infertile male."Archives of Andrology. 45. 181-185 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Lee, J. W., Kotliarova, S. E., Ewis, A. A., Hida, A., Shinka, T., Kuroki, Y., Tokunaga, K., Nakahori, Y.: "Y-chromosome compound haplotypes with the microsatellite markers"DXYS265, DXYS266, and DXYS241. J. Hum. Genet.. 46. 80-84 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Shinka, T., Naroda, T., Tamura, T., Sasahara, K., Nakahori, Y.: "A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC)."J. Hum. Genet.. 46. 263-266 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ewis, A. A., Kondo, K., Lee, J. W., Tsuyuguchi, M., Hashimoto, M., Yokose, T., Mukai, K., Kodama, T., Shinka, T., Monden, Y., Nakahori, Y.: "Occupational cancer genetics : Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers."Amer. J. lndust. Med.. 40. 92-97 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ewis, A. A., Lee, J. W., Naroda, T, Sasahara, K., Sano, T., Susumu Kagawa S., Iwamoto, T., Nakahori, Y.: "Linkage between prostate cancer incidence and different alleles of the human Y-linked tetranucleotide polymorphism DYS19."J. Med. Invest.. 49. 56-60 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Jabasini, M., Zhang, L., Dang, F., Xu, F., Almofli, F. R., Ewis, A. A., Lee, L. W, Nakahori, Y., Baba, Y.: "Analysis of DNA polymorphisms on the human Y-chromosome by microchip electrophoresis."Electrophoresis. 23. 1537-1542 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Lettice LA, Horikoshi T, Heaney SJ, van Baren MJ, van der Linde HC, Breedveld GJ, Joosse M, Akarsu N, Oostra BA, Endo N, Shibata M, Suzuki M, Takahashi E, Shinka T, Nakahori Y, Ayusawa D, Nakabayashi K, Scherer SW, Heutink P, Hill, RE, Noji S.: "Disruption of a long-range cis-acting regulator for Shh causes preaxialpolydactyly."Proc Natl Acad Sci USA. 99. 7548-7553 (2002)
Description
「研究成果報告書概要(欧文)」より
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