2002 Fiscal Year Final Research Report Summary
Construction of Artificial photosynthetic Reaction Center on Protein Surface: Toward Chemical Design of Photosynthetic-type Semisynthetic Enzyme
| Project/Area Number |
12480174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
HAMACHI Itaru Kyushu Univ., Institute for Fundamental Research of Organic Chemistry, Prof., 有機化学基礎研究センター, 教授 (90202259)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIJI Shinji Kyushu Univ., Graduate School of Engineering, Fellow of the Japan Society for the Promotion of Science for Japanese Junior Scientists, 工学研究院, 日本学術振興会特別研究員
OISHI Shigero Kitasato Univ. , Dept. of Chemistry, Prof., 理学部, 教授 (80213619)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Hemoprotein / Protein Engineering / Hybrid Protein / Charge separation State / Photosynthetic Reaction Center |
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| Research Abstract |
Toward engineering of hemoprotein structure and/or function, it is anticipated that a methodology to incorporate unnatural molecules into hemoproteins can greatly expand our ability to rationally and systematically manipulate their structure and function. What sorts of synthetic molecules can be incorporated into hemoproteins? What types of new functions can we produce from such semisynthetic hemoproteins? Hybridization of proteins or enzymes with photoelectronic molecules is promising for the synthesis of sophisticated biomaterials such as photo-biocatalysts, bioelectronic or optobioelectronic devices, and biosensors. In this paper, we describe our recent efforts to construct novel hemoprotein-based functional molecules and their properties, including topics of photo-control of the protein function, and photoinduced charge separation. Using cofactor reconstitution method, supramolecular ET systems were built in redox-active hemoprotein scaffold. Our research can be considered as a crossroad of protein engineering and supramolecular chemistry.
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