• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2002 Fiscal Year Final Research Report Summary

Research on functional substances from mushrooms showing preventing or curing effects on some diseases

Research Project

Project/Area Number 12490015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionShizuoka University

Principal Investigator

KAWAGISHI Hirokazu  Facultyof Agriculture, Professor, 農学部, 教授 (70183283)

Co-Investigator(Kenkyū-buntansha) MURATA Takeomi  Facultyof Agriculture, Associate Professor, 農学部, 助教授 (30273171)
TOKUYAMA Shinji  Facultyof Agriculture, Associate Professor, 農学部, 助教授 (60283347)
SUGIYAMA Kimio  Faculty of Agriculture, Professor, 農学部, 教授 (00126781)
Project Period (FY) 2000 – 2002
Keywordsmushrooms / liver injury / amyloid-β / anti-allergy / anti-oxidant / マトリックスメタロプロテアーゼ
Research Abstract

This project was done under the following subjects.
1) Suppressing substances against amyloid-β cytotoxicity
Since the mushroom Hericium erinaceum exhibited suppressing activity against Amyloid-β cytotoxicity, we tried to isolate the active principles from the mushroom. As a result, a kind of phosphatidyl ethanolamine was obtained. The structure was determined by spectroscopic methods such as NMR, MS, IR and so on.
2) Liver injury preventing substance
By the screening for liver injury preventing activity of mushrooms, we found that Lentinus edodes, Flammulina velutipes, and Grifola frondosa had potent activities. The isolation of active principles from the mushrooms are now in progress.
3) Anti-oxidant, anti-allergy, anti-tumor substances
The cultured mycelia of Phellinus linteus showed anti-oxidant, anti-allergy, and anti-tumor activities. Isolation of the active principles from the mushrooms are now in progress.
4) Matrix metallo-proteinase inhibitor
A matrix metallo-proteinase inhibitor was purified from the mushroom Piputoporus betulinus
5) Nerve growth factor inducer
Nerve growth factor inducers were obtained from the mycelia of Hericium erinaceum. The compounds were named as erinacines H and I.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Sano, Y.: "Ustalic acid as a Toxin and related compounds from the mushroom Tricholama vstalea"Chem. Commun.. 1384-1385 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawagishi, H.: "Alectin from an edible mushroom Pleurotus ostreatus as a food in take-suppressing substance"Biochim. Biophys. Acta. 1474. 299-308 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawagishi, H.: "Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii"Phytochemistry. 56. 53-58 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawagishi, H.: "Novel hydroguinone as a matrix metallo・proteinase inhibitor from the mushroom Piptoporus bethlinus"Biosci. Biotechnol. Biochem. 66. 2748-2750 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawagishi, H.: "Aldehyde dehydrogenase inhibitors from the mushroom clitocybe clavipes"J. Natl. Prod. 65. 1712-1714 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Lee, E-W: "Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum"Biosci. Biotechnol. Biochem. 64. 2402-2405 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河岸洋和(分担): "キノコとカビの基礎科学とバイオ技術"アイピーシー. 564 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawagishi H, Suzuki H, Watanabe H, Nakamura H, Sekiguchi T, Murata T, Usui T, Sugiyama K, Suganuma H, Inakuma T, Ito K, Hashimoto Y, Ohnishi-Kameyama M and Nagata T.: "A lectin from an edible mushroom pleurotus ostreatus as a food intake-suppressing substance"Biochim. Biophys. Acta. 1474. 299-308 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sano Y, Sayama K, Arimoto Y, Inakuma T, Kobayashi K, Koshino H and Kawagishi H: "Ustalic acid as a toxin and related compounds from the mushroom tricholoma ustale"Chem. Commun.. (13). 1384-1385 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagishi H, Takagi J, Taira T, Murata T and Usui T: "Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii"Phytochemistry. 56. 53-58 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagishi H, Hamajima K and Inoue Y: "Novel hydroquinone as a matrix metalloproteinase inhibitor from the mushroom, piptoporus betulinus"Biosci. Biotechnol. Biochem.. 66(12). 2748-2750 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagishi H, Miyazawa T, Kume H, Arimoto Y and Inakuma T: "Aldehyde dehydrogenase inhibitors from the mushroom clitocybe clavipes"J. Nat. Prod.. 65 (11). 1712-1714 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Lee Ew, Shizuki K, Hosokawa S, Suzuki M, Suganuma H, Inakuma T, Li J, Ohnishi-Kameyama M, Nagata T, Furukawa S and Kawagishi H: "Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum"Biosci. Biotechnol. Biochem.. 64 (11). 2402-2405 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura T, Akiyama Y, Matsugo S, Shibata K, Uzuka Y and Kawagishi H: "Purification of caffeic acid as an antioxidant from phellinus linteus nycelia"Int. J. Med. Mushr.. in press.

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2004-04-14  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi