| Project/Area Number |
12557104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
OKA Masaaki Yamaguchi University School of Medicine, Professor, 医学部, 教授 (70144946)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kotaro Yamaguchi University Hospital, Lecturer, 医学部附属病院, 助手 (50304481)
YOSHINO Shigefumi Yamaguchi University School of Medicine, Lecturer, 医学部, 助手 (60294633)
HAZAMA Shoichi Yamaguchi University Hospital, Assistant Professor, 医学部附属病院, 講師 (50253159)
YAHARA Noboru Yamaguchi University Hospital, Lecturer, 医学部附属病院, 助手 (80346569)
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| Project Period (FY) |
2000 – 2002
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| Keywords | pancreatic cancer / CTL / cell therapy / cancer-related peptide / cancer vaccine therapy / dendritic cell |
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| Research Abstract |
(1) Fifteen patients (stage III : 4, stage Iva : 8, stage Ivb : 3) with pancreatic cancer were treated by immunotherapy using MUC1-CTL after curative resection. Only one patient had liver recurrence. One year and 2 year survival rate were 80% and 21.4%, respectively. This immunotherapy may prevent liver metastasis after surgery, but can not control local recurrence.
(2) We performed phase I study of cancer peptide vaccine therapy for HLA-02 and -24 patients with unresectable pancreatic cancer. Three mg of peptides were administered with Freund's incomplete adjuvant subcutaneously. No sever adverse effect was observed. Seven of 10 patients had redness and edema in the injection sites. Three of 10 patients had NC and 7 had PD. One NC patient is still alive for 12 month. This vaccine therapy may be effective to control local lesion including regional lymph node metastasis.
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