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2002 Fiscal Year Final Research Report Summary

Therapy of neuropathic pain by using a gene-based approach of NF-κB decoy

Research Project

Project/Area Number 12557130
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

MASHIMO Takashi  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (60157188)

Co-Investigator(Kenkyū-buntansha) SHIBATA Masahiko  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (50216016)
KIYONO Hiroshi  Osaka University, Research Institute for Microbial Deseases, Professor, 微生物病研究所, 教授 (10271032)
Project Period (FY) 2000 – 2002
KeywordsNF-κB / decoy / heuropathic pain / cytokine / HVJ-liposome / 遺伝子導入
Research Abstract

Pro-inflammatory cytokines have been shown to be involved in the genesis, persistence, and severity of neuropathic pain following nerve injury. The transcription factor, nuclear factor-kappa B (NF-κB), palys a pivotal role in regulating pro-inflammatory cytokine gene expression. To elucidate the role of NF-κB in the pathogenesis of neuropathic pain, using a gene-based approach of NF-κB decoy, we tested whether the activated NF-κB affected pain behavior via the expression of inflammatory mediators. Single endoneurial injections' of, NF-κB decoy, at the site of nerve lesion, significantly alleviated thermal hyperalgesia for up to 2 weeks and suppressed the expression of mRNA of the inflammatory cytokines, iNOS, and adhesion molecules at the site of nerve injury. This finding suggests that a perineural inflammatory cascade, that involves NF-κB, is involved in the pathogenesis of neuropathic pain

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T: "NF-κB decoy supresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model."NeuroReport. 12. 2079-2084 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto N, Yamanaka H, Fukuoka T, Dai Y, Obata K, Mashimo T, Noguchi K: "Expression of HGF and cMet in the peripheral nervous system of adults rats following sciatic nerve injury."NeuroReport. 12. 1403-1407 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto N, Yamanaka H, Fukuoka T, Obata K, Mashimo T, Noguchi K.: "Expression of hepatocyte growth factor in primary sensory neurons of adult rats."Mol Brain Res. 97. 83-88 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Moricita R, Kiyono H, Noguchi K, Mashimo T.: "NF-κB decoy supresses cytokine expression and thermal hyperalgesia in a rat neuropatic pain model"NeuroReport. 12. 2079-2084 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto N, Yamanaka H, Fukuoka T, Dai Y, Obata K, Mashimo T, Noguchi K.: "Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury"NeuroReport. 12. 1403-1407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto N, Yamanaka H, Fukuoka T, Obata K, Mashimo T, Noguchi K.: "Expression of hepatocyte growth factor in primary sensory neurons of adult rats"Mol Brain Res. 97. 83-88 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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