2002 Fiscal Year Final Research Report Summary
Expression of enamel matrix protein in vitro
| Project/Area Number |
12557194
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGAOKA Shigetaka Kagoshima University, Dental School, Associate Professor, 歯学部, 助教授 (10155913)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Masato Hokkaido University, Dental School, Professor, 歯学部, 教授 (30236757)
TOKUDA Masayuki Kagoshima University, Dental School, Research Associate, 歯学部, 助手 (20253891)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Enamel protein / Periodontal tissue regeneration |
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| Research Abstract |
Several studies have examined the role of enamel matrix proteins in root formation and periodontal regeneration, although most of these have focused on a few specific genes which had previously been implicated. However, recent advances in expressional profiling have made it possible to examine the range of genetic responses involved in these processes. In the present experiments, we have therefore utilized this technique to determine the effects of enamel matrix proteins on the gene activities of periodontal ligament cells in vitro. Such cells were found to have an elevated level of RNA synthesis compared with control cells.
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