2002 Fiscal Year Final Research Report Summary
Synthesis and application of biologically-active multivalent-polymers
| Project/Area Number |
12558076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | NAGOYA UNIVERSITY (2001-2002)
Shizuoka University (2000) |
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Principal Investigator |
ARIMOTO Hirokazu NAGOYA UNIVERSITY GRADUATE SCHOOL OF SCIENCE ASSOCIATE PROFESSOR, 大学院・理学研究科, 助教授 (60262789)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGISHI Hirokazu SHIZUOKA UNIVERSITY FACULTY OF AGRICULTURE PROFESSOR, 農学部, 教授 (70183283)
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| Project Period (FY) |
2000 – 2002
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| Keywords | biological activity / polymer |
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| Research Abstract |
Synthesis of multi-valent polymer of glycopeptide antibiotics, vancomycin was investigated. The polymers exhibited enhanced antibacterial activity against vancomycin-resistant enterococci (VRE). The reaction conditions were optimized first, so that the polymers with different degree of polymerization could be obtained. Surface plasmon resonance study proved that the affinity between vancomycin polymers and bacterial cell wall precursors was greatly enhanced. The increased affinity would be important in antibacterial activity toward resistant bacteria. We synthesized block-copolymers of vancomycin and series of hydrophilic compounds.
Analytical method for these polymers was also investigated. Dynamic light scattering was found to be suitable for rapid and quantitative determinations of the degree of polymerizations.
Design and synthesis of oligomeric compounds anti-prion disease or anti-cancer were also done. These samples are under evaluations.
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