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2003 Fiscal Year Final Research Report Summary

INCREASED INCIDENCE OF BLADDER CANCER IN PEOPLE LIVING IN RADIOCONTAMINATED AREA OF UKRAINE AFTER THE CHERNOBYL DISASTER

Research Project

Project/Area Number 12576005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Experimental pathology
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

FUKUSHIMA Shoji  OSAKA CITY UNIVERSITY MEDICAL SCHOOL, DEPT.PATHOLOGY, PREFESSOR, 大学院・医学研究科, 教授 (00137077)

Co-Investigator(Kenkyū-buntansha) MORIMURA Keiichirou  OSAKA CITY UNIVERSITY MEDICAL SCHOOL, DEPT.PATHOLOGY, ASSISTANT PROFESSOR, 大学院・医学研究科, 講師 (30315999)
WANIBUCHI Hideki  OSAKA CITY UNIVERSITY MEDICAL SCHOOL, DEPT.PATHOLOGY, ASSOCIATE PROFESSOR, 大学院・医学研究科, 助教授 (90220970)
ALINA M Romanenko  INSTITUTE OF UROLOGY AND NEPHROLOGY ACADEMY OF MEDICAL SCIENCE OF UKRAINE, DEPT.PATHOLOGY, PROFESSOR AND DIRECTRATE
Project Period (FY) 2000 – 2003
KeywordsChernobyl accident / Bladder cancer / Chernobyl cystitis / Persistent low level exposure of radiation / Oxidative stress damage / Cancer related gene / p53 gene / Growth Factor Receptor
Research Abstract

After the Chernobyl accident, the incidence of urinary bladder cancers in Ukrainian is reported to increase 1.6 times within 15 years. Low level but persistent contamination of radioactive ^<137> Cs in the soil may be one of the main reasons for this increasing bladder cancer incidence. In this research project, we found out the increased incidence of dysplasia and/or bladder cancer including carcinoma in situ, was accompanied with increased ^<137> Cs level in urine among the people living in the radio-contaminated area, who showed no clinical symptoms of bladder cancer. Also we detected that a very specific chronic proliferative atypical cystitis with displastic lesions and/or carcinoma in situ was ubiquitously seen in the inhabitant of this radio-contaninated area. We defined this lesion as "Chernobyl cystitis". In this bladder lesion, several cancer related genes such as p53, p21 and Cyclin D1, were aberrantly expressed and iNOS and COX2 were over-expressed. These results point out … More to the great contribution of oxidative stress to the occurrence of cancer prone bladder lesions seen in this area. Moreover, we detected the difference in the incidences of p53 gene mutations in bladder cancers before and after Chernobyl accident, to be the possible distinct molecular carcinogenic pathway of bladder cancer formation in this area. To further investigate the mechanism underlying bladder carcinogenesis with this specific etiology, we investigated the expression level of growth factor receptor immunohistochemically. High expressions of FGF-R3, EGE-R1 and EGF-R2 were detected in bladder epithelia of radio-contaminated area, compared with those in clean area, and these growth factor receptors were suggested to play an important role in the bladder carcinogenesis after in the Chernobyl accident. From the sequence of the studies in this project, we demonstrated that people living in this radio-contaminated area were in peril of bladder cancer, and that a distinct molecular pathway might exist in the genesis of bladder cancer, based on this specific etiology. Less

  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Romanenko, A., Fukushima, S.et al.: "Increased oxidative stress with gene alteration in urinary bladder urothelium after the chernobyl accident."International Journal of Cancer. 86. 790-798 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto S., Fukushima S.et al.: "p53 status in multiple human urothelial cancers : assessment for clonality by the yeast p53 functional assay in combination with p53 immunohistochemistry."Japanese Journal of Cancer Research. 91. 181-189 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, S., Wanibuchi, H.: "Prevention of urinary bladder cancer : The interface between experimental and human studies."Asian Pacific Journal of Cancer Prevention. 1. 15-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima S.: "Possible involvement of O^6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis."Mutation Research. 477. 125-130 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Romanenko, A., Fukushima, S.et al.: "Correspondence re : W.Paile's Letter to the editor."Cancer Research. 61. 6964-6965 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Romanenko, A., Fukushima, S.et al.: "DNA damage repair in bladder urothelium after the chernobyl accident in ukraine."The Journal of Urology. 168. 973-977 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, S.et al.: "Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine."Japanese Journal of Cancer Research. 93. 1076-1082 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wanibuchi H., Fukushima S.et al.: "Lack of Inhibitory effects of an anti-angiogenesis drug, TNP-470, on rat urinary bladder papillomatosis induced by mechanical stimulation."Journal of Toxicologic Pathology. 15. 197-201 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, S.et al.: "Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline."Cancer letters. 191. 35-40 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, S.et al.: "Appropriate models and an understanding of carcinogenic mechanisms -requirements for hazard risk assessment."Asian Pacific Journal of Cancer Prevention. 4. 75-78 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Romanenko, A., Fukushima, S.et al.: "Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation."Cancer Science. 94. 328-333 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, S.et al.: "Theresholds for carcinogenicity of environmental carcinogens."Journal of Toxicologic Science. 28. 241-241 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morimura K., Fukushima S.et al.: "Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster."Oncology Reports. 11. 881-886 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima S, et al.: "Surgical pathology update 2001, 18th European congress of pathology"ABW Wissenschaftsverlag, Berlin, Genmany. 4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cohen, S.M., Fukushima, S.et al.: "Handbook of Toxicologic Pathology. Second Edition."Academic press. 26 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Vozianov, A.F., Romanenko, A., Fukushima, S.: "Health Effects of Chornobyl Accident."DIA Ltd.. 22 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima S., et al.: "Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline"Cancer letters. 191. 35-40 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima S., et al.: "Appropriate models and an understanding of carcinogenic mechanisms -requirements for hazard risk assessment"Asian Pacific Journal of Cancer Prevention. 4. 75-78 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Romanenko, A., Fukushima, S., et al.: "Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation"Cancer Science. 94. 328-333 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima S., et al.: "Theresholds for carcinogenicity of environmental carcinogens"Journal of Toxicologic Science. 28. 241-241 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimura K., Fukushima S., et al.: "Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster"Oncology Reports. 11. 881-886 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cohen, S.M., Fukushima, S., et al.: "Handbook of Toxicologic Pathology. Second Edition"Academic press. 26 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Vozianov, A.F., Romanenko, A., Fukushima, S: "Health Effects of Chornobyl Accident"DIA Ltd.. 22 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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