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2003 Fiscal Year Final Research Report Summary

Socio-medical research on the prevention and care of AIDS among women and children in Africa.

Research Project

Project/Area Number 12576015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionInternational Medical Center of Japan

Principal Investigator

WAKASUGI Naomi  International Medical Center of Japan, Department of Epidemiology Research Institute, Director, 疫学統計研究部, 部長 (20118459)

Co-Investigator(Kenkyū-buntansha) IKEDA Noriaki  International Medical Center of Japan, Department of Epidemiology Research Institute, Researcher, 疫学統計研究部, 研究員 (30150791)
TERUNUMA Hiroshi  Yamanashi Medical School, Department of Microbiology, Lecturer, 微生物学, 講師 (50217436)
Project Period (FY) 2000 – 2003
KeywordsHIV infection / AIDS / Africa / Reproductive Health / Socio-economic and Cultural state of women / Empowerment / Maternal and child health / Condom use / Mother to Child transmission of HIV
Research Abstract

Summary of the results
1. The role of women's empowerment as a factor facilitating condom use.
BACKGROUND : The increasing burden of HIV on women and children has led to an urgent need to identify factors that help women avoid the risk of HIV infection. Women's empowerment, such as by education and economic independence, has been suggested as a factor facilitating condom use but the data are inconclusive.
METHOD : Cross-sectional questionnaire surveys were conducted on the women in Madagascar, Mali, and Zambia, and analyzed.
RESULTS : Multivariate analysis showed that women's own earning significantly increased condom use (OR in Mali 4.00 (95%CI 1.28-12.5) ; Zambia, 1.73(95%CI 1.00-3.00) ; Madagascar, 1.69(95%CI 1.19-2.40)). However, women's education had not significant positive association with condom use in these countries. The chi-square test showed variable significances (Mali, p<0.05 ; Zambia, p=0.05 ; Madagascar, p<0.01), but meta-analysis using Mantel-Haenszel test showed a signifi … More cant association between own earning and condom use (p<0.001). The t test showed variable results (Mali, p=0.37, Zambia, p=0.33 ; Madagascar, p<0.05), but meta-analysis using Fisher's method :
-2Σlog(pi)〜X^22k showed no significant association between education and condom use (p>0.1).
CONCLUSION : Women's own earning was shown as an important factor facilitating condom use. Inefficacy of education suggested in this study indicated the need to further investigate what is lacking in education in-and-outside school, such as concrete and effective education regarding HIV and sex.
2. Increased risk of intrauterine transmission of HIV-1 associated with granulocyte elastase in the endocervical mucous.
Background : One of the remaining challenges in the prevention of mother-to-child transmission of HIV is to reduce the risk of the transmission during pregnancy.
It remained to be investigated what factors are affecting intrauterine HIV transmission and how they can be identified and intervened during pregnancy.
Methods : Granulocyte elastase in the endocervical mucous of HIV-positive pregnant women in Zambia were measured, and its association with intrauterine transmission of HIV 1 from mother to fetus was investigated.
Results : The intrauterine transmission rate determined by polymerase chain reaction assay of DNA from neonates at birth was 15.3%. The risk for intrauterine transmission was 8.65 fold higher in women positive for granulocyte elastase than in those who were negative.
Conclusions : We suggest that the women showing positive granulocyte elastase at delivery are strongly suspected to have and to have had chorioamnionitis during pregnancy, and it could affect the intrauterine transmission of HIV. Less

  • Research Products

    (47 results)

All 2006 2005 2004 2003 2002 2001 2000

All Journal Article (43 results) Book (4 results)

  • [Journal Article] Increased risk of intrauterine transmission of HIV-1 associated with granulocyte elastase in the endocervical mucous.2006

    • Author(s)
      Christine Kaseba-Sata, Francis Kasolo, Koji Ichiyama, Satoshi Mitarai, Ayako Nishiyama, Nohiro Kanayama, Naomi Wakasugi
    • Journal Title

      Journal of AIDS 41(2)

      Pages: 149-251

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased risk of intrauterine transmission of HIV-1 associated with granulocyte elastase in the endocervical mucous.2006

    • Author(s)
      Christine Kaseba-Sata, Francis Kasolo, Koji Ichiyama, Satoshi Mitarai, Ayako Nishiyama, Naohiro Kanayama, Naomi Wakasugi.
    • Journal Title

      Journal of AIDS 41(2)

      Pages: 249-251

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] HIV-母子感染の現状と今後の方向2005

    • Author(s)
      若杉なおみ
    • Journal Title

      小児科臨床別冊「子どものための国際保健医療協力-各論- 58

      Pages: 1361-1369

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 女性と子どものエイズーリスクの回避と脆弱性の減少に何が必要か?2005

    • Author(s)
      若杉なおみ
    • Journal Title

      アフリカ研究 67

      Pages: 107-120

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ザンビア共和国のエイズと結核の状況ーラボラトリーが担う役割り2005

    • Author(s)
      若杉なおみ
    • Journal Title

      モダンメディア 51(3)

      Pages: 53-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ジェンダーの視点からのエイズ克服2005

    • Author(s)
      若杉なおみ
    • Journal Title

      アフリカ地域のエイズ調査からふぇみん

      Pages: 2769

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Socioeconomic and reproductive factors associated with condom use within and outside of marriage among urban pregnant women in Zambia.2005

    • Author(s)
      Chipepo Kankasa, Margaret Siwale, Francis Kasolo, Ayako Nishiyama, Hiroshi Terunuma, Naomi Wakasugi
    • Journal Title

      Africa Journal of Reproductive Health 9(3)

      Pages: 127-132

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Socioeconomic and reproductive factors associated with condom use within and outside of marriage among urban pregnant women in Zambia.2005

    • Author(s)
      Chipepo Kankasa, Margaret Siwale, Francis Kasolo, Ayako Nishiyama, Hiroshi Terunuma, Naomi Wakasugi
    • Journal Title

      African Journal of Reproductive Health 9(3)

      Pages: 127-132

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] FGMの起源と文化-女性の健康とジェンダー・セクシュアリティの視点から2004

    • Author(s)
      若杉なおみ
    • Journal Title

      地域研究(国立民族学博物館) 6(1)

      Pages: 159-179

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Child death and women's earnings are associated with condom use in Madagascar.2004

    • Author(s)
      Randrianarivo A, Razafinanefa M, Rasolomaharo M, Nishiyama A, Wakasugi N
    • Journal Title

      Tropical Medicine and Health 32(1)

      Pages: 27-30

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The role of women's empowerment as a factor facilitating condom use-Metaanalysis : the results from African countries.2004

    • Author(s)
      Naomi Wakasugi, Ayako Nishiyama, Armand Randrianarivo, Assitan Sacko, Margaret Siwale, Chipepo Kankasa
    • Journal Title

      XV International AIDS Congerence International pROCEEDINGS e710s3358.

      Pages: 113-116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Child death and women's earnings are associated with condom use in Madagascar.2004

    • Author(s)
      Randrianarivo, A., Razafinanefa, M., Rasolomaharo, M., Nishiyama, A., Wakasugi, N.
    • Journal Title

      Tropical Medicine and Health 32(1)

      Pages: 27-30

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The role of women's empowerment as a factor facilitating condom use - Metaanalysis : the results from African countries.2004

    • Author(s)
      Naomi Wakasugi, Ayako Nishiyama, Armand Randrianarivo, Assitan Sacko, Margaret Siwale, Chipepo Kankasa.
    • Journal Title

      XV International AIDS Conference International Proceedings E710S3358

      Pages: 113-116

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prevalence of Drug-resistance-associated mutations in antiretroviral-drug-naive Zambians infected with subtype C HIV-1.2003

    • Author(s)
      Handema R, Terunuma H, Kasolo F, Kasai H, Sichone M, Yamashita A, Deng X, Mulundu G, Ichiyama K, Yokota T, WAkasugi N, Tezuka F, Yamamoto N, Ito M
    • Journal Title

      AIDS Research and Human Retroviruses 19(2)

      Pages: 151-161

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 子宮内HIV母子感染の危険因子-細菌性膣症/絨毛膜羊膜炎2003

    • Author(s)
      若杉なおみ, 金山尚裕, 西山綾子, Francis Kasolo, 御手洗聡, 市山浩二, Christine Laseba-Sata
    • Journal Title

      The Journal of AIDS Research 5(4)

      Pages: 391(187)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 世界のHIV母子感染の現状と予防対策2003

    • Author(s)
      若杉なおみ
    • Journal Title

      Journal of bio-Medical Science association 15(1)

      Pages: 15-21

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] アフリカ社会に深く埋めこまれた慣習FGM : 健康とジェンダー・セクシュアリティの視点から2003

    • Author(s)
      若杉なおみ
    • Journal Title

      アフリカレポート(アジア経済研究所) 37

      Pages: 21-27

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A pilot of VCT and the prevention of mother-to-child transmission of HIV in a primaruy health center at Bamako,Mali.2003

    • Author(s)
      Wakasugi, N, ASssitan, S
    • Journal Title

      Tropical Medicine and Health 32(1)

      Pages: 143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] What is effective and worthwhile cooperarion with Africa?2003

    • Author(s)
      Wakasugi, N, Zambia, Malawi
    • Journal Title

      tropical Medicine and Health 32(1)

      Pages: 75-77

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] HIV/AIDS of women and children : Avoidance of risk and reduction of vulnerability.2003

    • Author(s)
      Wakasugi, N
    • Journal Title

      1st International congerence of risk management for preventive medicine(abstract)

      Pages: 148

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cervical granulocyte elastase increases the risk of intrauterine mother-to-child transmission of HIV.2003

    • Author(s)
      Nishiyama, A, Kaseba・S.C, Kasolo F, Mitarai S, Ichiyama K, Wakasugi N
    • Journal Title

      13th International Conference on AIDS and STIs in AFrica(Abstract)

      Pages: 156

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prevalence of Drug-resistance-associated mutations in antiretroviral-drug-naive Zambians infected with subtype C HIV-1.2003

    • Author(s)
      Handema R., Terunuma H., Kasolo F., Kasai H., Sichone., M., Yamashita A., Deng X., Mulundu G., Ichiyama, K., Yokota T., Wakasugi.N., Tezuka F., Yamamoto N., Ito M.
    • Journal Title

      AIDS Research and Human Retroviruses 19(2)

      Pages: 151-160

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A pilot of VCT and the prevention of mother-to-child transmission of HIV in a primary health center at Bamako, Mali.2003

    • Author(s)
      Wakasugi, N., Assitan, S.
    • Journal Title

      Tropical Medicine and Health 32(1)

      Pages: 143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] What is effective and worthwhile cooperation with Africa?2003

    • Author(s)
      Wakasugi, N., Zambia, Malawi
    • Journal Title

      Tropical Medicine and Health 32(1)

      Pages: 75-77

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] HIV/AIDS of women and children : Avoidance of risk and reduction of vulnerability.2003

    • Author(s)
      Wakasugi, N.
    • Journal Title

      18^<th> International conference of risk management for preventive medicine (abstract) 148

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cervical granulocyte elastase increases the risk of intrauterine mother-to-child transmission of HIV.2003

    • Author(s)
      Nishiyama, A., Kaseba-S, C., Kasolo, F., Mitarai, S., Ichiyama, K., Wakasugi, N.
    • Journal Title

      13^<th> International Conference on AIDS and STIs in Africa (Abstract) 156

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] サブサハラアフリカ(マリ、ザンビア、マダガスカル)における女性のHIV感染防御に関するリプロダクテイブヘルス要因と社会経済文化要因2002

    • Author(s)
      若杉なおみ, 西山綾子
    • Journal Title

      第17回日本国際保健医療学会誌

      Pages: 71

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] フランスにおけるアフリカ移民を主としたHIV母子感染予防対策の現状2002

    • Author(s)
      若杉なおみ, Nicole CIRARU VIGNERON.
    • Journal Title

      The Journal of AIDS Research 4(4)

      Pages: 309(187)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] アフリカのHIV母子感染-ジレンマの克服と今後の展望-2002

    • Author(s)
      若杉なおみ
    • Journal Title

      The Journal of AIDS Research 4(2)

      Pages: 66(14)-75(23)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lung diseases at necropsy in African children dying from respiratory illnesses : a descriptive necropsy study.2002

    • Author(s)
      Chntu C, Mudenda V, Lucas S, Nunn A, Lishimpi K, Maswahu S, Kasolo F, Mwava P, Bhat G, Terunuma H, Zumla A
    • Journal Title

      Lancet 360(9338)

      Pages: 985-990

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ザンビアでのエイズ母子感染予防に対する取り組み2002

    • Author(s)
      若杉なおみ
    • Journal Title

      Confronting HIV 20

      Pages: 4

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of Pneumocysts carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses2002

    • Author(s)
      Loshimpi K, Kasolo F, Chintu C, Mwaba P, Mudenda V, Maswahu D, Terunuma H, Fletcher H, Nunn A, Lucas S, Zumla A
    • Journal Title

      AIDS 16(6)

      Pages: 932-934

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lung diseases at necropsy in African children dying from respiratory illnesses : a descriptive necropsy study.2002

    • Author(s)
      Chintu C, Mudenda V, Lucas S, Nunn A, Lishimpi K, Maswahu D, Kasolo F, Mwaba P, Bhat G, Terunuma H, Zumla A.
    • Journal Title

      Lancet 360(9338)

      Pages: 985-990

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses.2002

    • Author(s)
      Lishimpi K, Kasolo F, Chintu C, Mwaba P, Mudenda V, Maswahu D, Terunuma H, Fletcher H, Nunn A, Lucas S, Zumla A.
    • Journal Title

      AIDS 16(6)

      Pages: 932-934

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ザンビア・るかさ市の妊婦における、HIVの性感染、母子・母乳感染に対する知識と授乳法選択に関するKAP調査2001

    • Author(s)
      西山綾子, M.Siwale, C.Kankasa, F.Kasolo, 照沼裕, 若杉なおみ
    • Journal Title

      第16回日本国際保健医療学会誌

      Pages: 52

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ザンビア妊産婦のHIV感染と女性の教育・収入との関連2001

    • Author(s)
      若杉なおみ, 西山綾子, 照沼裕
    • Journal Title

      The Journal of AIDS Research 3(4)

      Pages: 422(238)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antibody masking renders HIV^1 resistant to the cationic membrane filtration through alteration of its electrostatic character.2001

    • Author(s)
      Owada, T., Terunuma, H et al.
    • Journal Title

      J.Virological Methods 94

      Pages: 15-24

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ザンビアでのJICAの「エイズおよび結核対策プロジェクト」について2001

    • Author(s)
      照沼裕
    • Journal Title

      Confronting HIV 18

      Pages: 4

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antibody masking renders HIV-1 resistant to the cationic membrane filtration through alteration of its electrostatic character.2001

    • Author(s)
      Owada, T., Terunuma, H.et al.
    • Journal Title

      J.Virological Methods 94

      Pages: 15-24

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] マダガスカルにおけるHIV/STI防御(コンドーム使用)と女性のエンパワメントの関連2000

    • Author(s)
      若杉なおみ, 永井周子
    • Journal Title

      第15回国際保険医療学会誌

      Pages: 131

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 化学療法の領域2000

    • Author(s)
      照沼裕, 沼崎義夫
    • Journal Title

      16

      Pages: 483-488

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Oral mucosal screening as an integral part of general health screening2000

    • Author(s)
      Toru Nagao, Noriaki Ikeda et al.
    • Journal Title

      Jpurnal of medical screening 7

      Pages: 203-208

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Oral mucosal screening as an integral part of general health screening.2000

    • Author(s)
      Toru Nagao, Noriaki Ikeda et al.
    • Journal Title

      Journal of medical screening 7

      Pages: 203-208

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 「エイズ」(国際保健医療学会編・杏林書院)2005

    • Author(s)
      若杉なおみ
    • Total Pages
      201-206
    • Publisher
      国際保健医療学 改訂版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 「国際保健医療の現状と課題 アフリカ」(国際保健医療学会編・杏林書院)2001

    • Author(s)
      若杉なおみ
    • Total Pages
      234-237
    • Publisher
      国際保健医療学
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 「世界の公衆衛生体系」マダガスカル共和国2000

    • Author(s)
      若杉なおみ
    • Total Pages
      433-446
    • Publisher
      日本公衆衛生協会出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 「世界の公衆衛生体系」象牙海岸共和国2000

    • Author(s)
      若杉なおみ
    • Total Pages
      369-383
    • Publisher
      日本公衆衛生協会出版
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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