2002 Fiscal Year Final Research Report Summary
Molecular Epidemiological studu of Oral and Maxillofacial disorders among the residents of the Semipalatinsk Nuclear Test Site Area
| Project/Area Number |
12576025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Surgical dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
OKAMOTO Tetsuji Hiroshima Univ. Graduate Scho. Of Biomed. Sci., Professor, 大学院・医歯薬学総合研究科, 教授 (00169153)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Masaharu Hiroshima Univ., Res. Institute for Radiation Biology and Medicine, Professor, 原爆放射線医科学研究所, 教授 (50099090)
AKAGAWA Yasumasa Hiroshima Univ. Graduate Scho. Of Biomed. Sci., Professor, 大学院・医歯薬学総合研究科, 教授 (00127599)
TANAKA Yoshiharu Hiroshima Univ. Graduate Scho. Of Biomed. Sci., Research Associate, 大学院・医歯薬学総合研究科, 助手 (50304431)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Semipalatinsk Nuclear Test Site / Radiation Exposure / Cleft-Lip Palte / IL-1α genotypw / IL-1β genotype / Missing teeth number / congenital anomally / Oral-maxillofacial disorder |
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| Research Abstract |
From 1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out at the Semipalatinsk Nuclear Test Site (SNTS). The aim of this study was to investigate the radiation effect to the maxillo-facial region in the heavily exposed and control population of similar ages (<10 years old) at the time of most harmful atmospheric nuclear weapons testing in 1949-1956. We have found an apparently strong association between radioactive fallout exposure and the high frequency of tooth loss due to severe periodontitis among the screened population from exposed villages Sarzhal and Dolon. This study suggests more detailed molecular research of the nature of tooth loss in the heavily exposed population. In the screened inhabitants from heavily exposed villages Sarzhal and Dolon the high average number of missing teeth was observed in all genotype polymorphisms and statistically were not associated. The high frequency of tooth loss due to severe periodontitis among the inhabitants from the heavily exposed villages Sarzhal and Dolon may be related to the harmful environmental influence, including ionizing radiation. The significance of factor A (p<0.001), which implies the degree of environmental differences in the population from Sarzhal, Dolon and Kokpekty ; the same ethnicity, oral hygiene, nutritional and smoking habit of the inhabitants from the exposed and control villages support this conclusion as well. Inhabitants from the exposed villages Sarzhal and Dolon might be considered as a population at risk for high frequency of tooth loss as a result of radiation exposure and further follow-up study is needed for them. This study suggests more detailed molecular research of the nature of dental disorders in the area surrounding the SNTS.
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[Publications] Koike, C., Shimizu, Y., Yama-michi, N., Ito, T., Kameda, T., Michimukai, E., Kitamira, N., Okamoto, T., Iba, H.: "Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431"Oncogene. 21. 2670-2678 (2002)
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「研究成果報告書概要(和文)」より
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[Publications] Kobayashi, M., Kishida, S., Fukui, A., Michiue, T., Miyamoto, Y., Okamoto, T., Yoneda, Y., Asashima, M., Kikuchi, A.: "Nuclear localization of Duplin, a b-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway"J. Biological Chemistry. 22:277. 5816-5822 (2002)
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[Publications] Furue, M., Myoishi, Y., Fukui, Y., Ariizumi, T., Okamoto, T., Asashima.M.: "Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro"Proc. Natl. Acad. Sci. USA.. Vol.99. 15474-15479 (2002)
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[Publications] Ojika, M., Islam Kamrul, Shintani, T., Zhang, Y., Okamoto, T., Sakagami, Y.: "Cytotoxic Acyispermidines from a Soft Coral : Three New Cytotoxic Acyispermidines from a Soft Coral, Sinularia sp"Biosci. Biotechnol. Biochem.. (印刷中). (2003)
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「研究成果報告書概要(和文)」より
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[Publications] Ojika M., Islam Kamrul, Shintani, T., Zhang, Y., Okamoto, T., Sakagami, Y.: "Cytotoxic Acylspermidines from a Soft Coral : Three New Cytotoxic Acylspermidines from a Soft Coral, Sinularia sp"Biosci. Biotechnol. Biochem.. in press. (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kobayashi, M., Okamoto, T., Yoneda, Y., Asashima, M., Kikuchi, A., et al.: "Nuclear localization of Duplin, a b-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway"J. Biological Chemistry. 22:277. 5816-5822 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Furue, M., Zhang, Y., Okamoto, T., Hata, R., and Asashima, M.: "Activin A induces expression of rat Sel-1l mRNA, a negative regulator of notch signaling, in rat salivary gland-derived epithelial cells"Biochemical and Biophysical Research Communications. 282. 745-749 (2001)
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[Publications] Liu, X., S. Shi, J.-H. Chen, D. Wu, M. Kan, Y. Myoken, T. Okamoto, J.D.: "Kluwer Academic Publishers"Sato (2001) Human fibroblast growth factor-binding protein HBp17 enhances the tumorigenic potential of immortalized squamous epithelial cells, Animal Cell Technology : Basic and Applied Aspects, vol.12. 343-352 (2001)
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「研究成果報告書概要(欧文)」より
