2001 Fiscal Year Final Research Report Summary
Involvement of endogenous opioid in maintenance of running behavior of rats
| Project/Area Number |
12610097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
実験系心理学
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| Research Institution | HYOGO COLLEGE OF MEDICINE |
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Principal Investigator |
ISO Hiroyuki Hyogo College of Medicine,medical,Associate Professor, 医学部, 助教授 (80068585)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Running behavior / Reinforcement mechanism / Endogenous opioid / Activity stress / Rat / Mouse |
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| Research Abstract |
The 1st phase : The mechanisms to reinforce high frequent running behavior in rodents were examined. The running behavior of male Wistar rats in the running wheel situation during extinction schedule was suppressed by the injection of 0.3mg/kg of naloxone. However, the free running or running avoidance responses of rats were not affected by the opioid blocker.
The 2nd phase : High frequent running in the activity stress paradigm was assessed using mice as subjects. In the first experiment, C57BL and BALB/c mice were maintained in the paradigm (Ihr/day food restriction in the running wheel) for 3 days showed severe stress symptoms (stomach ulceration, reduction in spleen weight, increase of the adrenal glands, increase in liver methalotionein, and death), more in the BALB/c mice. In the second experiment, the development of stress pathology of C57BL mice was assessed and it was found that the effect of stress developed gradually.
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