2001 Fiscal Year Final Research Report Summary
The study on the morphogenesis of peroxisomes employing a targeting signal and its receptors
| Project/Area Number |
12670012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
USUDA Nobuteru Fujita Health University, School of Medicine, Professor, 医学部, 教授 (30135123)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJO Keiju Shinshu University School of Medicine, Research Associate, 医学部, 助手 (10252074)
NAKAZAWA Ayami Fujita Health University, School of Medicine, Research Associate, 医学部, 助手 (90273078)
KARASAWA Nobuyuki Fujita Health University, School of Medicine, Assistant Professor, 医学部, 講師 (70148287)
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| Project Period (FY) |
2000 – 2001
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| Keywords | peroxisomes / signal peptides / targeting signals / morphogenesis |
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| Research Abstract |
Peroxisomes have been stained by expressing a fusion protein of green fluorescent protein with a targeting signal in its C-terminus (GFP-SKL), introduced to cultured cells by trasfection procedure and to mice by making a trasgenic mouse. The object of the study is to elucidate the mechanism of morphogenesis, with these cells and transgenic mouse as materials. The present study was attempted to show the appearance of peroxisomes during cell division, embryonic development and by the administration of peroxisome proliferators. A tansgenic mouse expressing. GFP-SKL has been developed and biochemical and morphological analyses are on the way. Morphological analyses in cultured cells expressing GFP-SKL have been analyzed and on the way of publication. Related subjects on peroxisomes have been published.
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[Publications] Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K: "High serum IgG4 concentrations in patients with sclerosing pancreatitis"N Engl J Med. 344 (10). 732-8 (2001)
Description
「研究成果報告書概要(欧文)」より
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