2002 Fiscal Year Final Research Report Summary
Studies on physiological characteristics of an inbred rat with resistance adaptation to heat and searches for related-genes
| Project/Area Number |
12670064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
FURUYAMA Fujiya Nagoya City University, Graduate School of Medical Sciences, Assistant Professor, 大学院・医学研究科, 講師 (00080101)
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| Co-Investigator(Kenkyū-buntansha) |
NISHINO Hitoo Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (60073730)
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| Project Period (FY) |
2000 – 2002
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| Keywords | heat / The inbred FOK rat / stress-tolerance / hyperosmolality / heat stroke / genetics / sepsis / adaptation |
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| Research Abstract |
We studied the characteristics of the inbred FOK rat with genotypic resistance adaptation to heat and related-genes were searched. In addition, brain injury in control strain of rats *erfusion of surgically extirpated salivary glands. The evidence suggested that evaporative cooling was regulated with mode of negative feedback control by central nervous system. FOK rats showed interesting responses to other stresses than heat. FOK rats largely responded to psychological stress and lipopolysaccharide with large fever. We previously reported that FOK rats were cold resistant. In the present study, a hormone largely increased in cold-exposed FOK rats. Genes which are congenitally expressed in the hypothalamus of FOK rats were searched using cDNA MicroArray analysis. Three genes thought to be highly expressed in the hypothalamus of FOK rats. These findings thought to be beneficial for health care in strongly stressed condition in various situations.
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[Publications] Kuwabara E, Furuyama F, Ito K, Tanaka E, Hayashi T, Hattan N, Fujikura H, Kimura K, Goto T, Taira H, Shinozaki Y, Umetani K, Hyodo K, Tanioka K, Mochizuki R, Kawai T, Koide S, Mori H.: "Inhomogeneous vasodilatory response of rat tail arteries to heat stress : Evaluation by synchrotron radiation microangiography"Jpn J. physiol.. 52. 403-408 (2002)
Description
「研究成果報告書概要(欧文)」より
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