• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2001 Fiscal Year Final Research Report Summary

Roles of the neurohypophyseal hormones released from the dendrites in the control of stress responses

Research Project

Project/Area Number 12670066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJichi Medical School

Principal Investigator

ONAKA Tatstushi  Jichi Medical School, Department of Physiology, Associate Professor, 医学部, 助教授 (90177254)

Project Period (FY) 2000 – 2001
Keywordsstress / vasopressin / oxytocin / noradrenaline / dendrites / microdialysis / hypothalamus / medulla oblongata
Research Abstract

Vasopressin and oxytocin are synthesized in the magnocellular neurosecretory neurones in the hypothalamus, transported to the axon terminals in the neurohypophysis, and released into the blood stream. Not only from the axon terminals, vasopressin and oxytocin are released also from the dendrites in the hypothalamus. In the present study, we examined roles of vasopressin or oxytocin released from the dendrites in neurosecretory responses to stressful stimuli. We firstly demonstrated that noradrenaline neurons in the A1 region of the medulla oblongata mediate oxytocin release from the neurohypophysis after noxious stimuli, while A2 noradrenergic neurons mediate oxytocin responses to conditioned fear stimuli. We then confirmed that stressful stimuli such as intermittent footshocks facilitate vasopressin release from the dendrites/cell bodies in the hypothalamus via a microdialysis method. We also examined effects of vasopressin or oxytocin upon noradrenaline release in the hypothalamus. Exogenous application of vasopressin or oxytocin facilitated noradrenaline release in response to high K^+ solution, and a vasopressin or oxytocin receptor antagonist attenuated them. An oxytocin receptor antagonist also impaired noradrenaline release in the hypothalamus and oxytocin release from the neurohypophysis after noxious stimuli. From all these data we conclude that vasopressin or oxytocin released from the dendrites has an augmentative role in the activity of neurosecretory neurons via facilitation of noradrenaline release in the hypothalamus.

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Ludwig M: "Vasopressin regulation of noradrenaline release within the supraoptic nucleus"J Neuroendocrinol. 12. 477-479 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onaka T: "Catecholaminergic mechanisms underlying neurohypophysial hormone responses to unconditioned or conditioned aversive stimuli"Exp Physiol. 85S. 101S-110S (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamashita T: "Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus"NeuroReport. 12. 3509-3511 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onaka T: "Medullary Al noradrenergic neurones may mediate oxytocin release after noxious stimuli"Neuroreport. 12. 2499-2502 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Leng G: "Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: an experimental and theoretical analysis"J Neurosci. 21. 6967-6977 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Xiu L: "Facilitation of Ca^<2+> store-dependent noradrenaline release after an NMDA receptor antagonist in the rat supraoptic nucleus"J Neuroendocrinol. 13. 894-904 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Xiu L: "Nicotine facilitates noradrenaline release in the rat supraoptic nucleus"J Neuroendocrinol. 12. 641-643 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onaka T: "Involvement of N-methyl-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats"J Neuroendocrinol. 13. 166-174 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hada T: "Effects of novel environmental stimuli on neuroendocrine activity in thoroughbred horses"J Equine Sci. (In press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 尾仲達史: "競走馬とストレス"体育の科学. 50. 623-627 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 羽田哲朗: "サラブレッド若馬の血漿コルチゾル、カテコールアミン、バゾプレシンおよびオキシトシン濃度に対する新奇環境刺激の影響"馬の科学. 38. 14-20 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 尾仲達史: "バゾプレシン神経、オキシトシン神経とストレス"Clinical Neuroscience. 19. 1145-1148 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 尾仲達史: "ストレス"Clinical Neuroscience. 19. 1318-1319 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ludwig M., Onaka T., Yagi K.: "Vasopressin regulation of noradrenaline release within the supraoptic nucleus"J Neuroendocrinol. 12. 477-479 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka T.: "Catecholaminergic mechanisms underlying neurohypophysial hormone responses to unconditioned or conditioned aversive stimuli"Exp Physiol. 85S. 101S-110S (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita T., Liu X., Onaka T., Honda K., Saito T., Yagi K.: "Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus"Neuro Report. 12. 3509-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka T., Yamashita T., Liu X., Honda K., Saito T., Yagi K.: "Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli"Neuroreport. 12. 2499-2502 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Leng G., Brown CH., Bull PM., Brown D., Scullion S., Currie J., Blackburn-Munro RE., Feng J., Onaka T., Verbalis JG., Russell JA., Ludwig M.: "Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: an experimental and theoretical analysis"J Neurosci.. 21. 6967-77 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Xiu L., Onaka T., Yagi K.: "Facilitation of Ca^<2+> store-dependent noradrenaline release after an NMDA receptor antagonist in the rat supraoptic nucleus"J Neuroendocrinol. 13. 894-904 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Xiu L., Onaka T., Yagi K.: "Nicotine facilitates noradrenaline release in the rat supraoptic nucleus"Neuroreport. 12. 641-643 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka T., Yagi K.: "Involvement of N-methy1-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats"J Neuroendocrinol. 13. 166-174 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hada T., Onaka T., Kusunose R., Yagi K.: "Effects of novel environmental stimuli on neuroendocrine activity in thoroughbred horses"J Equine Sci.. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2003-09-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi