2001 Fiscal Year Final Research Report Summary
Functional analyses of the CNC transcription factor Nrf3 in colon cancer and T cell development
| Project/Area Number |
12670104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KOBAYASHI Akira Tohoku university school of medicine, Research Associate, 大学院・医学系研究科, 助手 (50292214)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Transcriptional regulation / transcription factor / cancer development / apoptosis / T cell |
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| Research Abstract |
Transcription factor Nrf3 is supposed to play roles in colon cancer and T cell development. Previous results tell us that Nrf3 is digested with Caspase9, resulting in cell death. So I examined function of Nrf3 in colon cancer, T cell development and apoptosis.
1) For examination of physiological roles of Nrf3, I generated a Nrf3 gene targeting mouse (knock out mouse) and a T cell-specific overexpression transgenic mouse.
2) Nrf3 knockout mouse is viable and fertile. Phenotype are observed in T cell and a certain sensorium.
3) Nrf3 overexpression transgenic mice were lethal. This data shows us that overexpression of Nrf3 is toxic to cells.
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