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2001 Fiscal Year Final Research Report Summary

Analysis of DNA sequence of immunoglobulin heavy chain variable region gene in lymphomas developing from chronic inflammation

Research Project

Project/Area Number 12670159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

AOZASA Katsuyuki  Osaka Univ Graduate Sch Med, Professor, 医学系研究科, 教授 (30115985)

Co-Investigator(Kenkyū-buntansha) NAKATSUKA Shinichi  Osaka Univ Graduate Sch Med, Assist Prof, 医学系研究科, 助手 (90303940)
TAKAKUWA Tetsuya  Osaka Univ Graduate Sch Med, Assist Prof, 医学系研究科, 助手 (40244933)
TOMITA Yasuhiko  Osaka Univ Graduate Sch Med, Associate Prof, 医学系研究科, 助教授 (60263266)
Project Period (FY) 2000 – 2001
Keywordsimmunoglobulin gene / thyroid lymphoma / Hashimoto's thyroiditis / pyothorax-associated lymphoma
Research Abstract

Immunoglobulin heavy chain variable region gene was analyzed in lymphomas developing from chonic inflammation of different etiology to evaluate whether lymphoma cells proliferate inresponse to specific antigenic stimuli.
In thyroid lymphomas, usage of VH26 was observed. Because usage of VH26 is also reported, this finding indicated that thyroid lymphoma develops among the pool of activated lymphoid cells which appear in Hashimoto's thyroiditis. Thyroid lymphoma is a tage of germinal center cells and show somatic mutation suggesting these is in response to some antigenic stimuli.
Pyothorax-associated lymphoma(PAL) is at the stage of post-germinal center cells, in which antigenic selection in proliferating lymphoma cells is unlikely.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Takakuwa T, Aozasa K et al.: "Microsatellite instability and k-ras, p53 mutation in thyroid lymphoma"Jpn J Cancer Res. 91. 280-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hongyo T, Aozasa K et al.: "Specific c-kit mutations in nasal NK/T-cell lymphoma in China and Japan"Cancer Res. 60. 2345-2347 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takakuwa T, Aozasa K et al.: "Expression of interleukin 7and its receptor in thyroid lymphoma"Lab Invest. 80. 1483-1490 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakatsukas, Aozasa K et al.: "Role of hypermethyration of DAP-kinase CpG island in the development of thyroid lymphoma"Lab Invest. 80. 1651-1656 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takakuwa T, Aozasa K et al.: "Frequent mutations of Fas gene in thyroid lymphoma"Cancer Res. 61. 1382-1385 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura K, Aozasa K et al.: "Dexamethasone as a potent growth inhibitoe of androgen-indeperdext prostate cancer"J Natl Cancer Iast. 93. 1739-1746 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] <Takakuwa T>___________-, <Aozasa K>_________-, et al.: "Microsatellite instability and k-ras, p53 mutations in thyroid lymphoma"Jpn J Cancer Res. 91. 280-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hongyo T, <Aozasa K>_________-, et al.: "Specific c-kit mutations in nasal NK/T-cell lymphoma in China and japan"Cancer Res. 60. 2345-2347 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] <Takakuwa T>___________-, <Aozasa K>_________-, et al.: "Expression of interleukin 7 and its receptor in thyroid lymphoma"Lab Invest. 80. 1483-1490 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] <Nakatsuka S>____________-, <Aozasa K>_________-, et al.: "Role of hyper-methylation of DAP-kinase CpG island in the development of thyroid lymphoma"Lab Invest. 80. 1651-1656 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] <Takakuwa T>___________-, <Aozasa K>_________-, et al: "Frequent mutations of Fas gene in thyroid lymphoma"Cancer Res. 61. 1382-1385 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura K, <Aozasa K>_________-, et al.: "Dexamethasone as a potent growth inhibitor of androgen-independent prostate cancer"J Natl Cancer Inst. 93. 1739-1746 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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