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2001 Fiscal Year Final Research Report Summary

Effects of polymorphism and lifestyle for the fractions of serum LDL cholesterol

Research Project

Project/Area Number 12670355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionShimane Medical University

Principal Investigator

SHIWAKU Kuninori  MEDICAL SCHOOL, SHIMANE MEDICAL UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 助教授 (10108384)

Project Period (FY) 2000 – 2001
KeywordsLDL / Small, dense LDL / Visceral obesity / Food / Exercise / Education / Polymorphism / β3-adrenergic receptor
Research Abstract

We conducted epidemiological studies of small, dense LDL and oxidized LDL, which were suggested risk factors for coronary heart diseases, in Japanese and Mongolian.
1) The international comparative research for Japanese and Mongolian
A study of epidemiological investigation was carried out for 283 of Japanese and 258 of Mongolian aged 30-60 years old. Japanese and 258 of Mongolian with small, dense LDL had higher BMI, higher of serum triglyceride, insulin, leptin and oxidized LDL, and lower of serum HDL blood, compared to persons with intermediate or large LDL size. The prevalence of small, dense LDL in Mongolian who had many growing fat was lower than Japanese. These results suggest that small, dense LDL is related with unknown factors, except for obesity, serum triglyceride, VLDL.
2) Interventional study by self-learning and self-determination for visceral obesity
Number of participants decreased with their body weight was 23 (51 %) in 2000 and 30 (73 %) in 2001. An improvement of LDL size by the intervention was 25 in 2000 and 33 in 2001. It related to increase in a degree of life activities strongly, and a decrease of serum triglyceride and insulin resistance, increase in serum HDL cholesterol. A decrease in serum LDL concentration was not associated plasma oxidized LDL by the intervention. Plasma oxidized LDL was higher concentration in persons with small, dense LDL than persons with bigger size of LDL. Persons with small, dense LDL had higher concentration of oxidized LDL in dense gravity of LDL fraction, compared with persons with bigger size of LDL. It became clear that small, dense LDL contained higher oxidized LDL modified with the side chain of apoB.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 塩飽邦憲 他: "内臓脂肪型肥満に対する自己学習と自己決定に基づく教育プログラムの開発"日本医学看護学教育学会誌. 11(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 乃木章子 他: "健康な労働者における肥満とb3-アドレナリン受容体遺伝子多型の関連"島根女子短期大学紀要. 37. 1-8 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Shiwaku, et al.: "Vasomotor and other menopausal symptoms influenced by menopausal stage and psychosocial factors in Japanese middle-aged women"Journal of Occupational Health. 43. 356-364 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 塩飽邦憲 他: "保健医療福祉の地方分権と自治体の役割"公衆衛生. 66. 196-199 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 塩飽邦憲 他: "市場経済に揺れるモンゴルの保健医療福祉"公衆衛生情報. 32(11). 44-47 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 塩飽邦憲 他: "農村における生活習慣病とQOL"日本農村医学会雑誌. 50(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A. Nogi, K. Shiwaku, Y. Yamane: "Lifestyle-related diseases and educational issues for dietitian"Jpn J Medical and Nursing Education. 10 (In Japanese). 28-32 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku: "Healthy workers and healthy workshop"Public Health Information. 30(10) (In Japanese). 48-49 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku, et al.: "Vasomotor and other menopausal symptoms influenced by menopausal stage and psychosocial factors in Japanese middle-aged women"J Occup Health. 43. 356-364 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Nogi, K. Shiwaku, et al.: "The relationship between obesity and polymorphism of β3-adrenergic receptor gene"Bulletin of Shimane Women's College. 37 (In Japanese). 1-8 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku, Y. Yamane: "Human development of manpower in health and welfare divisions of municipalities"Public Health. 65 (In Japanese). 564-568 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku: "Health policy of Mongolia to shake with the market economy"Public Health Information. 32(11) (in Japanese). 44-47 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Yamane, K. Shiwaku, et al.: "Issues of health and welfare in municipalities with the progress of in decentralization"Public Health. 66 (In Japanese). 114-119 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku, E. Tarui: "Decentralization and the Long-term Care Insurance system"Public Health. 66 (In Japanese). 196-199 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku, et al.: "Evaluation of industry health support system in community"Indust Health. 25(2) (in press) (in Japanese). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku, et al.: "Development of health educational program for visceral obesity by self-learning and self-determination"Jpn J Medical and Nursing Education. 11 (in press) (in Japanese). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku: "lifestyle-related diseases and QOL in rural communities"Jpn Assoc J Rural Med. 50 (in press) (In Japanese). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiwaku: "Healthy Cities and Municipalities in case of Sada Town"Jpn Assoc J Rural Med. 50 (in press) (In Japanese). (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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