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2001 Fiscal Year Final Research Report Summary

RESEARCH FOR MAKING AN INQUIRY ABOUT PATHOLOGY OF CHRONIC LIVER DISEASE ASSOCIATD WITH HCV INFECTION

Research Project

Project/Area Number 12670358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

TANAKA Junko  FACULTY OF MEDICINE, HIROSHIMA UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 講師 (70155266)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Toshio  FACULTY OF MEDICINE, HIROSHIMA UNIVERSITY, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (20136089)
KATAYAMA Keiko  FACULTY OF MEDICINE, HIROSHIMA UNIVERSITY, RESEARCH ASSOCIATE, 医学部, 助手 (50304415)
YOSHIZAWA Hiroshi  FACULTY OF MEDICINE, HIROSHIMA UNIVERSITY, PROFESSOR, 医学部, 教授 (30109954)
KUMADA Hiromitsu  TORANOMON HOSPITAL, DIRECTOR, 消化器科, 部長
Project Period (FY) 2000 – 2001
KeywordsHCV carriers / Natural courses / Markov process / Mathematical model / Incidence of HCC
Research Abstract

We presented natural courses of HCV carriers using mathematical model by Marcov process. This Model is based on clinical courses of HCV carriers of various clinical stages. According to this model, we assessed efficacy of intervention, such as examination and treatment for HCV carriers, to reduce mortality of hepatocellular carcinoma (HCC) associated with HCV infection. From this, we concluded in the following three ways.
First, we made the model of natural course of HCV carrier by Marcov process. The model include five clinical stages ; asymptomatic carriers, chronic hepatitis, liver cirrhosis, HCC, and resolution of HCC infection.
Second, we recalculated the mathematical model on data of clinical course of 942 HCV carriers, who were found at the chance of blood donation. We estimated that incidence of HCC among asymptomatic carriers at the age of 40 years old was 10.6% in male and 4.5% in female. And we estimated that the incidence of HCC was very high in male over 60 years old and in female 70 years old.
Third, using the recalculated model, we get two clinical courses of HCV carrier from normal population in two cases, in one case they were screened for HCV carriers and in the other case they were not.

  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 吉澤浩司: "ウイルス肝炎発生の動向調査"日本公衆衛生雑誌. 47・5. 461-462 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司: "肝癌検診-病因論に基づいた検診のあり方とHCV感染の疫学的背景-"肝臓病学の進歩. 26. 2-19 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司, 他: "病因論に基づいた肝炎・肝がん対策"Ortho HCV Frontier. 1. 2-19 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司: "C型肝炎ウイルス肝炎の疫学"肝炎・肝がん対策にむけて""医療情報誌・Schneller. 42. 2-5 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司, 他: "B型肝炎ウイルス感染の疫学(2)"B型肝炎の新しい展開 第22回犬山シンポジウム. 14-17 (2001)

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  • [Publications] 片山惠子, 他: "HCV感染者の動向と感染経路"臨床病理. 49・8. 741-746 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 田中純子, 他: "肝がん、肝炎検診"がん検診の適正化に関する調査研究事業 新たながん検診手法の有効性の評価報告書. 325-362 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] 田中純子, 他: "HCVキャリアの自然史解明の試み-マルコフモデルを用いた検討-"日本公衆衛生雑誌. 48・10. 817 (2001)

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  • [Publications] 吉澤浩司, 他: "地域住民を対象としたHCV検診-1992年度から2000年度までの総括-"広島医学. 54・12. 1001-1005 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] Yoshizawa H.: "Hepatocellular Carcinoma Associated with Hepatitis C virus Infection in Japan ; Projection to Other Countries in the Foreseeable Future"Oncology. 62・1. 8-17 (2002)

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      「研究成果報告書概要(和文)」より
  • [Publications] 田中純子, 他: "日本のHCVキャリア数の推定 自覚症状がないまま潜在するHCVキャリア数"臨床医. 28・1. 2-6 (2002)

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  • [Publications] 片山恵子, 他: "わが国における肝炎ウイルスキャリアの動向"医学のあゆみ. 200・1. 3-8 (2002)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司, 他: "慢性肝炎診療のためのガイドライン"日本肝臓学会. 14 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤浩司: "病因論に基づいた肝炎・肝がん対策 学術講演会講演録"岩手県予防医学協会. 15 (2001)

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  • [Publications] 田中純子, 他: "慢性肝炎診療マニュアル"医学書院. 138 (2001)

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  • [Publications] 吉澤浩司, 他: "ウイルス肝炎 診断、予防、治療-ウイルス肝炎対策の指針-"文光堂. 115 (2002)

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  • [Publications] Yoshizawa H: "Trend of viral hepatitis"Japanese Journal of Public Health. 47 (5) (in Japanese). 461-467 (2000)

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  • [Publications] Katayama K, et al: "Past Trends in Hepatitis C Virus Infection and Route of Transmission in Japan"Official Journal of Japanese Society of Laboratory Medicine. 49 (8) (in Japanese). 741-746 (2001)

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  • [Publications] Yoshizawa H, et al: "HCV screening for residents. -Report from 1992 to 2000-"Journal of the Hiroshima Medical Association. 54 (12) (in Japanese). 1001-1005 (2001)

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  • [Publications] Tanaka J, et al: "Screening for HCC and hepatitis"Report of "evaluation of efficacy for new examination methods for cancer." in Research Group of Ministry of Health, Labour and Welfare. (in Japanese). 325-362 (2001)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka J, et al: "Trial of making inquiry natural course of HCV carrier using Markov process"Japanese Journal of Public Health. 48 (10) (in Japanese). 817 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshizawa H: "Hepatocellular Carcinoma Associated with Hepatitis C virus Infection in Japan ; Projection to Other Countries in the Foreseeable Future"Oncology. 62 (1). 8-17 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshizawa H, et al: "Viral Hepatitis - Diagnosis, Prevention, Treatment -"Bunkodo (in Japanese) (Japanese Book). (2002)

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Published: 2003-09-17  

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