2001 Fiscal Year Final Research Report Summary

Analysis of TCR antagonism on patients having variant HCV

Research Project

Project/Area Number	12670511
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Gastroenterology
Research Institution	Jichi Medical School
Principal Investigator	KANEKO Takashi Jichi Medical School, Department of Medicine, Assistant, 医学部, 助手 (10254913)
Co-Investigator(Kenkyū-buntansha)	ASABE Shinichi Jichi Medical School, Department of Medicine, Assistant, 医学部, 助手 (60281680)
Project Period (FY)	2000 – 2001
Keywords	Chronic Hepatitis / Hepatitis C virus / T cell receptor / cytotoxic T lymphocyte / Immunology / antagonism
Research Abstract	In the model experiment assuming that a subtle amount of variant HCV virus emerged in wild one, we previously showed that a 1/1000 amount of variant virus greatly inhibited CTL induction and the remaining CTL population, if any, did not recognize the variant virus itself. In this report, we analyzed the CTL in the patient in whom the variant virus had replaced the wild one already. In that patient, we found three CTL populations. One recognized only the variant virus, another did weakly both of the variant one and the wild one, and the other did only the wild one. And we could not find TCR antagonism using the variant virus as a sub optimal stimulator. Nevertheless, three CTL populations existed in the patient, we could not induce the CTL recognizing both the variant one and the wild one using the variant virus as a stimulator.

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