2002 Fiscal Year Final Research Report Summary
Roles of oxidative stresses in neurodegeneration and myodegeneration focusing on the heme catabolism
| Project/Area Number |
12670588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKEDA Atsushi Tohoku University, Neurology, Research Associate, 大学院・医学系研究科, 助手 (70261534)
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| Project Period (FY) |
2000 – 2002
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| Keywords | oxidative stresses / RNA oxidation / nucleic acid oxidation / Alzheimer disease / Parkinson disease / multiple system atrophy |
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| Research Abstract |
Through this project, we revealed that increased levels of RNA oxidation were commonly observed in brains affected with neurodegenerative diseases including Alzheimer disease, Parkinson disease and dementia with Lewy bodies. The oxidized RNAs were prominently identified in the affected brain lesions in their early stages, and were decreased wish the progression of diseases. Furthermore, the end product of RNA oxidation, 8-hydroxy guanosine (8OHG), was increased in the serum and CSF samples of Parkinson disease and multiple system atrophies. It is suggested that the levels of 8OHG can be applied for the diagnostic biomarker of neurodegenerative diseases.
We also identified that the RNA oxidation was associated wish the degenerative changes in smyopathies wish rimmed vacuoles. Through our investigation, it was shown that oxidative stresses might play a key roles in myodegeneration.
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Research Products
(14 results)
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[Publications] Kikuchi A., Takeda A., Onodera H., Kimpara T., Hisanaga K., Sato N., Nunomura A., Castellani RJ., Perry G, Smith MA., Itoyama Y.: "Systemic increase of oxidaive nucleic acid damage in Parkinson's disease and multiple system atrophy"Neurobiology of Diseases. 9. 244-248 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Smith MA., Drew KL., Nunomura A., Takeda A., Hirai K., Zhu X., Atwood CS., Raina AK., Rottkamp CA., Sayre LM., Friedland RP., Perry G: "Amyloid-beta, tau alternations and mitochondrial dysfunction in Alzheimer disease : chickens or the egg?"Neurochemisny International. 40. 527-531 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Perry G, Nunomura A., Hirai K., Zhu X., Prez M., Avila J., Castellani RJ., Atwood CS., Aliev G, Sayre LM., Takeda A., Smith MA.: "Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?"Free Radical Biology & Medicine. 33. 1475-1479 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Smith MA., Drew KL., Nunomura A., Takeda A., Hirai K., Zhu X., Atwood CS., Raina AK., Rottkamp CA., Sayre LM., Friedland RP., Perry G.: "Amyloid-beta, tau alternations and mitochondriat dysfunction in Alzheimer disease : chickens or the egg?"Neurochemistry International. 40. 527-531 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Perry G., Nunomura A., Hirai K., Zhu X., Perz M., Avila J., Castellani RJ., Atwood CS., Aliev G., Sayre LM., Takeda A., Smith MA.: "Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?"Free Radical Biology & Medicine.. 33. 1475-1479 (2002)
Description
「研究成果報告書概要(欧文)」より
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