2001 Fiscal Year Final Research Report Summary
The study of reorganization of the brain function during recovery of hemiparesis by movement-related
| Project/Area Number |
12670618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Teikyo University School of Medicine |
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Principal Investigator |
SIMIZU Natsue Teikyo University School of Medicine, Dept. of Neurology, Professor, 医学部, 教授 (80095017)
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| Project Period (FY) |
2000 – 2001
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| Keywords | HEMIP ARESIS / REORGANIZATION OF THE BRAIN FUNCTI0N / FINGER MEVEMENT / fMRI / CEREBROVASCULAR ACCIDENT |
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| Research Abstract |
We have previously investigated the readiness potential of patients with hemiparesis due to a single stroke and showed that an ipsilateral hemisphere was frequently activated more than that of a contralateral hemisphere in paretic finger movements.
To investigate such reorganization of brain function after a cerebrovascular accident (CVA), we evaluated functional magnetic resonance imaging (fMRI) of patients with hemiparesis from a recent CVA.
Four patients in subacute stage (10 - 45 days) of CVA and one normal subject were studied using MM. Subjects performed three tasks of self-paced flexion of the second finger for normal hand, paretic hand and both hands The task performance occurred in 20 seconds after 20-second ''rest" period. The cycle of rest and task performance was repeated 3 times during each experiment. All MRI experiments were performed with a 1.5T scanner (General Electric Signa Horizon LX). The study has been approved by the Institutional Review Board of Teikyo University
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School of Medicine, Ichihara Hospital. After the purpose and procedure of the study was explained, each subject gave written informed consent for the study.
Activation in contralateral sensorimotor area, surrounding subcortical area and supplementary motor area was observed in unilateral finger movements. Activation of bilateral sensorimotor areas, surrounding subcortical areas and supplementary motor areas was observed in bilateral finger movements. The area of activation was smaller in the normal than that of patients. However, no patients showed activation of contralateral sensorimotor area and synkinesia of contralateral hand. In paretic finger movement one patient showed displacement of contralateral sensorimotor area, one showed more activation of contralateral sensorimotor area and one showed no activation of supplementary motor area.
Strategy of voluntary movements appeared to be different in each subject. Contrary to previous reports, activation of normal sensorimotor area in paretic finger movement and more activation of supplementary motor area were not observed in our small number of patients. Further analysis will be necessary. Less
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