2001 Fiscal Year Final Research Report Summary
MOLECULAR ANALYSIS OF CANCER FAMILY SYNDROME
| Project/Area Number |
12670743
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | GIFU UNIVERSITY |
|---|
Principal Investigator |
KANEKO Hideo GIFU UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, ASSOCIATE PROFESSOR, 医学部附属病院, 講師 (80293554)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUKAO Toshiyuki GIFU UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, ASSOCIATE PROFESSOR, 医学部附属病院, 講師 (70260578)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Keywords | BLM / ATM / ATM kinase activity / phosphorylation / telomerase / SUMO-1 |
|---|
| Research Abstract |
(1) We showed thati in Epstein-Barr-virus transformed lymphoblastoid cell lines and lymphoma cells from BS patients, telomerase activity was detected as compared with the control. BLM is not a major structural and regulatory factor in maintaining telomere repeat length and telomerase activity
(2) We showed that the Arg^<1344>-Ser^<1345>-Lys^<1346>-Arg^<1347> sequence at the C-terminus of the human BLM protein was essential for nuclear localization of this protein.
(3) We demonstrated that immunoblot analysis using EBV-transformed or PHA-stimulated lymphoblastas represented a useful approach for laboratory diagnosis for A-T.
(4) We showed that the N-terminal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
|
Research Products
(32 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] Fukao T., Yoshida T., Kaneko H., X-Q., Song., Tashita, H., Teramoto T., Inoue R., Watters D., Lavin M., Kondo N.: "Immunoblot analysis for laboratory diagnosis of ataxia-telangiectasia : Use of Epstein-Barr virus-transformed or phytohemagglutinin-stimulated lymphoblasts for detection of ATM protein"Invest. Allergol. Clin. Immunol.. 10. 36-40 (2000)
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Publications] Kondo N., Matui E., Kaneko H., Kato Z, Fukao T., Teramoto T., Inoue R., Watanabe M., Sakaguchi H., Kasahara K., Morinoto N.: "Role of IL-12 receptor β 2 mutations in the development of atopy"ACI International supplement. No. 1. 92-94 (2000)
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Publications] Kondo N., Matui E., Kaneko H., Kato Z., Fukao T., Teramoto T., Inoue R., Watanabe M., Sakaguchi H., Kasahara K., Morimoto N.: "Reduced interferon-γ production and mutations of the IL-12 receptor β 2 chain gene in atopic subjects"Int. Arch. Allergy. Immunol.. 124. 117-120 (2001)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
[Publications] Terada T., Kaneko H., Li A-I., Kasahara K., Ibe M., Yokota S., Kondo N.: "Analysis of IgG subclass deficiency. : First reported case of IgG2, IgG4 and IgA deficiency caused by deletion of Cα1, φCγ1, Cγ2, Cγ4 and Cε in a Mongoloid patient"J. Allergy Clin. Immunol.. 108. 602-6 (2001)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Watanabe M., Kaneko H., Shikano H., Aoki M., Sakaguchi H., Matui E., Inoue R., Kato Z., Kasahara K., Fukutomi O., Kondo T., Kondo N.: "Predominant expression of 950delCAG of IL-18R alpha chain cDNA is associated with reduced IFN-gamma production and high serum IgE level in atopic patients"J. Allergy Clin. Immunol.. (in press). (2002)
Description
「研究成果報告書概要(欧文)」より
-
-
