In Vitro Simulation of NBCA Embolization for Arteriovenous Malformation

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 12670864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: INAGAWA Shoichi Dept of radiology, Hamamatsu University School of Medicine, clinical lecturer, 医学部・附属病院, 助手 (60303567)
• Co-Investigator(Kenkyū-buntansha): ISODA Haruo Dept of radiology, Hamamatsu University School of Medicine, assistant professor, 医学部・附属病院, 講師 (40223060)
• Project Period (FY): 2000 – 2001
• Keywords: Arteriovenous Malformation / Blood flow / Embolization / NBCA / In vitro simulation

Research Abstract

Background : Embolization using n-butyl-cyanoacrylate (NBCA) for arteriovenous malformation (AVM) is now a daily practice over the world. But how to control it is learned only on clinical practice, and there exists no system to simulate it in vitro. Method : Isoda's circuit (AJNR 18 ; 1463-72,1997) is hired to produce pulsatile flow, and connected to a nidus model made of a one-mi syringe filled with small beads. A microcatheter is introduced just before the nidus model. Digital subtraction angiography (DSA) is performed to calculate transit time of the contrast medium (CE) through the nidus. Various rate of NBCA is injected with an autoinjector. Results : Transit time of CE through the nidus model is fairly constant. With 50% mixture of NBCA, slower injection led to slower filling of the syringe gradually from the proximal end to the distal one. Discussion and Conclusion : NBCA embolizaiton could be simulated in vitro.