2003 Fiscal Year Final Research Report Summary
The Study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias from the perspective of abnormal cytoskeletons
| Project/Area Number |
12670952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University School of Medicine |
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Principal Investigator |
ISEKI Eizo Yokohama City University School of Medicine, associate professor, 医学部, 助教授 (30203061)
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| Co-Investigator(Kenkyū-buntansha) |
ODAWARA Toshinori Yokohama City University School of Medicine, the sane clove, associate professor, 医学部附属病院, 助教授 (00244426)
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| Project Period (FY) |
2000 – 2003
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| Keywords | dementia with Lewy bodies / Lewy body / α-synuclein / phosphorylated raw / frontotemporal / Pick's disease / ubiquitin |
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| Research Abstract |
The study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias has been performed from the perspective of abnormal cytoskeletons. Cytopathological and clinicopathological studies of dementia with Lewy bodies (DLB) have been focused. In the cytopathological studies, formation process or degeneration process of Lewy bodies was investigated using α-synuclein immunohistochemistry. Lewy bodies were formed by the accumulation of α-synuclein in the abnormal cytoskeletons with axonal transport blockage, and degenerated with glial and immunological reaction. In the clinicopathological studies, Lewy pathology was graded from stage I to stage IV, and autopsied cases of DLB were classified into some subtypes according to the degree of Lewy pathology or Alzheimer pathology. In frontotemporal dementia (FTD), Pick's disease (PiD) was divided into two types of tauopathy and ubiquitinopathy.
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