2001 Fiscal Year Final Research Report Summary
The therapeutic effect of vaccination on neuronal change in animal models with Alzheimer disease
| Project/Area Number |
12670960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
TADOKORO Mamoru St. Marianna University, School of Medicine Pathology, Professor, 医学部, 教授 (80081644)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Mitsubumi St. Marianna University, School of Medicine Pathology, Assistant Professor, 医学部, 講師 (30231971)
SAKIYAMA Takeshi St. Marianna University, School of Medicine Pathology, Associate Professor, 医学部, 助教授 (20130510)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Alzheimer disease / amvloid plague / amyloid-β-peptide / model mouse |
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| Research Abstract |
It has recently been reported that amyloid injection (vaccine) into PDAPD mice resulted in marked decrease of amyloid plaque deposition (APD), although it is uncertain whether or not amyloid plaque is the real cause of Alzheimer disease. Amyloid- β -peptide injection into animal models of Niemann-Pick disease type C (NPC) mice (spm, NIH) and Down syndrome (Dn) mice was projected in that whether or not such vaccination effects the brain tissue with APD and neurofibril change, APD itself is responsible for Alzheimer's etiology, and vaccine is an effective therapy. The pathological difference is only slight between NPC-spm and NPC-NIH mice, but the life span is shorter in NIH mice. We then vaccinated spm mice every 2 weeks. The clinical manifestation and life span were not different from non-vaccined mice. Neurologically, glial reaction of astrocytea was slightly affected in vaccinated mice. To evaluate the long span effect, Dn mice were vaccinated up to 10 months (8 month vaccination). Neural atrophy in cerebral cortex and hippocampus was progressive from 4 -month-old mouse to 10 -month-old mouse. Ten- month-old mouse showed calcification in pallidum and gliosis in basal forebrain. However, gliosis in cerebral subcortex of white matter, stained with GFAP was milder.
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