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2002 Fiscal Year Final Research Report Summary

Causes of Hyper-α-lipoproteinemia and its relevance to atherosclerosis

Research Project

Project/Area Number 12671102
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionNiigata University

Principal Investigator

MIIDA Takashi  NIIGATA university medical hospital, Lecturer, 医学部附属病院, 講師 (80260545)

Project Period (FY) 2000 – 2002
KeywordsAtherosclerosis / HDL-cholesterol / Cholesteryl Ester Transfer Protein / Hepatic Lipase
Research Abstract

High-density lipoprotein (HDL) is the anti-atherogenic lipoprotein that removes excess cholesterol from peripheral tissues an d transports it to the liver for the excretion. Epidemiological studies have clearly shown that low HDL-cholesterol level is as sociated with the high incidence of atherosclerotic disorders such as coronary artery disease (CAD). However, it is still controversial whether very high HDL-cholesterol level is favorable for the prevention of CAD. In this study, we examined the causes of hyper-α-lipoproteinemia (HAL) and its relation to atherosclerotic disorders. We obtained the following results ; (1) We determined the frequency of HAL (HDL-cholesterol【greater than or equal】100mg/dL) in 2,229 healthy subjects. HAL was found in 7 out of 1,033 men (0.7%), and 14 out of 1,196 women (1.2%), respectively. (2) We measured CETP mass in fasting serum from 83 HAL and control subjects. In men (n=26), the cholesteryl ester transfer protein (CETP) mass was significantly lower in … More HAL than in those with normal HDL-cholesterol level (1.6±0.6 vs. 2.2±0.5gμ/mL, p<0.001). In women (n=57), on the other hand, the CETP level was similar between HAL and control subjects (2.5±0.8 vs. 2.4±0.5 μg/mL). (3) Nondenaturing two-dimensional gel electrophoresis revealed that large- and medium-sized HDL with alpha-mobility (HDL2b, and HDL2a) were significantly higher in HAL subjects than in control subjects. It is noteworthy that prebetal-HDL, the initial acceptor of cellular cholesterol, also increased significantly in HAL. (4) Treadmill exercise electrocardiography was carried out in 42 (12 men and 30 women, aged 21-73 years) out of 83 HAL patients who were free from symptoms of ischemic heart disease. Although two patients (4.8%) showed significant ST depression during exercise, both of them were false positive. These results indicate that low CETP activity is more important in male HAL than in female HAL in Japan. Whether HAL promotes CAD remained to be determined in the future study. Less

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Miida T, et al.: "Prepβ1-high-density lipoprotein concentration can change with low-density lipoprotein-cholesterol concentration independent of cholesteryl ester transfer protein"Clinica Chimica Acta. 292. 69-80 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miida T, et al.: "Bezafibrate increases preβ1-HDL at the expense of HDL2b in hypertriglyceridemia"Arteriosclerosis, Thrombosis and Vascular Biology. 20. 2428-2433 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada M, et al.: "Autoantibodies against oxidized low-density lipoprotein concentration correlate with Achilles tendon xanthoma"Clinical Chemistry and Laboratory Medicine. 38. 501-506 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada M, et al.: "Possible risk factors of carotid artery atherosclerosis in the Japanese population -A primary prevention study in non-diabetic subjects -"Internal Medicine. 39. 362-368 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyazaki O, et al.: "A new sandwich enzyme immunoassay for measurement of plasma pre-β-HDL levels"Journal of Lipid Research. 41. 2083-2088 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kurabayashi T, et al.: "Eicosapentaenoic acid effect on hyperlipidemia in menopausal Japanese women"Obstetrics and Gynecology. 96. 512-528 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inano K, et al.: "Capillary isotachophoretic analysis of serum lipoproteins using carrier ampholyte as spacer ion"Annals of Clinical Biochemistry. 37. 708-716 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakatsume M, et al.: "Novel glomerular lipoprotein deposits associated with apolipoprotein E2 homozygosity"Kidney International. 59. 1911-1918 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taira K, et al.: "LR11, a mosaic LDL receptor family member, mediates the uptake of apoE-rich lipoproteins in vitro"Arteriosclerosis, Thrombosis and Vascular Biology. 21. 1501-1506 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okumura-Noji K, et al.: "Cholesteryl ester transfer protein-deficiency causes slow egg embryonation of Shistosoma Japanicum"Biochemical Biophysical Research Communications. 286. 305-310 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murai T, et al.: "Fenofibrate inhibits reactive amyloidosis in mice"Arthritis and Rheumatism. 46. 1683-1688 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maruyama S, et al.: "Fenofibrate, a peroxisome proliferator-activated receptor α activator, suppresses experi-mental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats"Journal of Atherosclerosis and Thrombosis. 9. 87-92 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miida T, et al.: "LDL-cholesterol and HDL-cholesterol decrease during the day"Annals of Clinical Biochemistry. 39. 241-249 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miida T, et al.: "Analytical performance of a sandwich enzyme immunoassay for preβ1 high-density lipoprotein in stabilized plasma"Journal of Lipid Research. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miida T, et al.: "LCAT-dependent conversion of preβ1-HDL into α-migrating HDL is severely delayed in hemodialysis patients"Journal of American Society of Nephrology. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miida T, et al.: "Preβ1-high-density lipoprotein concentration can change with low-density lipoprotein-cholesterol concentration independent of cholesteryl ester transfer protein"Clinica Chimica Acta. Vol. 292. 69-80 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miida T, et al.: "Bezafibrate increases preβ1-HDL at the expense of HDL2b in hypertriglyceridemia"Arteriosclerosis, Thrombosis and Vascular Biology. Vol. 20. 2428-2433 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada M, et al.: "Autoantibodies against oxidized low-density lipoprotein concentration correlate with Achilles tendon xanthoma"Clinical Chemistry and, Laboratory Medicine. Vol. 38. 501-506 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada M, et al.: "Possible risk factors of carotid artery Atherosclerosis in the Japanese population -A primary prevention study in non-diabetic subjects-"Internal Medicine. Vol. 39. 362-368 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyazaki O, et al.: "A new sandwich enzyme immunoassay for measurement of plasma pre-β1-HDL levels"Journal of Lipid Research. Vol. 41. 2083-2088 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kurabayashi T, et al.: "Eicosapentaenoic acid effect on hyperlipidemia in menopausal Japanese women"Obstetrics and Gynecology. Vol. 96. 512-528 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inano K, et al.: "Capillary isotachophoretic analysis of serum lipoproteins using carrier ampholyte as spacer ion"Annals of Clinical Chemistry. Vol. 37. 708-716 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakatsume M, et al.: "Novel glomerular lipoprotein deposits associated with apolipoprotein E2 homozygosity"Kidney International. Vol. 59. 1911-1918 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taira K, et al.: "LR11, a mosaic LDL receptor family member, mediates the uptake of apoE-rich lipoprotein in vitro"Arteriosclerosis, Thrombosis and Vascular Biology. Vol. 21. 1501-1506 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okumura-Noji K, et al.: "Cholesteryl ester transfer protein-deficiency causes slow egg embryonation of Shistosoma Japanicum"Biochemical Biophysical Research Comnunications. Vol. 286. 305-310 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murai T, et al.: "Fenofibrate inhibits reactive amyloidosis in mice"Arthritis and Rheumatism. Vol. 46. 1683-1688 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maruyama S, et al.: "Fenofibrate, a peroxisome proliferators-activated α activator, suppresses experimental autoimmune myocarditis by stimulating the ihterleukin-10 pathway in rats"Journal of Atherosclerosis and Thrombosis. Vol. 9. 87-92 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miida T, et al.: "LDL-cholesterol and HDL-cholesterol decrease during the day"Annals of Clinical Chemistry,. Vol. 39. 241-249 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miida T, et al.: "Analytical performance of a sandwich enzyme immunoassay for plasma preβ1 high-density lipoprotein in stabilized plasma"Journal of Lipid Research,. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miida T, et al.: "LCAT-dependent conversion of preβ1-HDL into α-migrating HDL is severely delayed in hemodialysis patients"Journal of American Society of Nephrology. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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