2001 Fiscal Year Final Research Report Summary
Experimental and Clinical Studied for process of gastric carcinogenesis
| Project/Area Number |
12671215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
SUGIYAMA Atsushi Shinshu University Hospital, Medical Care Networking Center, Associate Professor, 医学部・附属病院・医療福祉支援センター, 助教授 (90187675)
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| Project Period (FY) |
2000 – 2001
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| Keywords | gastric cancer / Helicobacter pylori / Phenotype of cancer / promotor effect / duodenogastric reflux / gastric mucin / α-4GnT mRNA / Prostaglandini |
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| Research Abstract |
The process of gastric carcinogenesis concerning Helicobacter pylori ( Hp ) was studied, and following results were obtained.
1. In Mongolian gerbil ( MG ) model Hp and chemical carcinogen induce several phenotype of gastric cancer, but intestinal metaplasia may be a direct precursor only in a subset of the intestinal-type tumors.
2. In the relationship between Hp and gastric carcinogenesis, Hp is a promoter rather than an initiator, and other environmental factors ( the timing of carcinogen administration ) play important roles.
3. Hp infection plus duodenogastric reflux increase cell proliferation in the gastric mucosa in MG model.
4. Hp eradication diminishes enhancing effect of Hp infection on glandular stomach carcinogenesis in MGs. Hp eradication may be useful as a prevention approach against stomach cancer.
5. In the early stage of Hp infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents.
6. As results, the expression level of a 4GnT mRNA tended to be increased in the pyloric mucosa with Hp infection, suggesting that Hp infection enhances the biosynthesis of gland mucous cell-type mucin.
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[Publications] Shimizu,N., Ikehara,Y., Inada,K., Nakanishi,H., Tsukamoto,T., Nozaki,K., Kaminishi,M., Kuramoto,S., Sugiyama,A., Katsuyama,T., Tatematsu,M.: "Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils"Cancer Res.. 60. 1512-1514 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Maruta,F., Sugiyama,A., Ishida,K., Ikeno,T., Murakami,M., Kawasaki,S., Ota,H., Tatematsu,M., Katsuyama,T.: "Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori"Cancer Letter. 160. 99-105 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Shimizu,N., Ikehara,Y., Nozaki,K., Kaminishi,M., Tsuda,H., Sugiyama,A., Katsuyama,T., Tatematsu,M.: "Effects of lactoferrin administation in Helicobacter pylori infection animal model"Lactoferrin: Structure, Function and Applications. K. Shimazaki et al. eds.. Elsevier Science B.V.. 209-215 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Sugiyama,A., Ikeno,T., Ishida,K., Maruta,F., Murakami,M., Sato,T., Saito,H., Ishizone,S., Kawasaki,S., Ota,H., Katsuyama,T.: "Paradoxical role of Helicobacter pylori infection -protective effect against ethano-induced gastric mucosal injury in Mongolian gerbils-Dig"Dis Sci. 46. 2433-2439 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kumagai,T., Yan,J., Graham,DY., Tozuka,M., Okimura,Y., Ikeno,T., Sugiyama,A., Katsuyama,T., Ota,H.: "Serum immunoglobulin G immune response to Helicobacter pylori antigens in Mongolian Gerbils"J Clinical Microbioloy. 39. 1283-1288 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Sugiyama,A., Ikeno,T., Maruta,F., Kawasaki,S., Hayama,M., Ota,H., Yoshizawa,A., Nakajima,K., Fukushima,M., Honda,H: "Long-term Helicobacter pylori colonization produces G cell hyperplasia and carcinoid tumor"J Cell Mol Med. 4. 308-309 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Maruta,F., Ota,H., Genta,M., Sugiyama,A., Tatematsu,M., Katsuyama,T., Kawasaki,S.: "Role of N-methyl-N-nitrosurea in the induction of intestinal metaplasia and gastric adenocarcinoma in Mongolian gerbils infected with Helicobacter pylori"Scand J Gastroenterol. 36. 283-290 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Tsuzuki,S., Ota,H., Hayama,A., Sugiyama,A., Akamatsu,T., Kawasaki,S.: "Proliferation of α -smooth muscle actin-containing stromal cells ( Myofibroblast ) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus"Scand J Gastroenterol. 35. 86-91 (2001)
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「研究成果報告書概要(欧文)」より
