2001 Fiscal Year Final Research Report Summary
Gene therapy for thrombosis
| Project/Area Number |
12671315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NISHIDA Takahiro Faculty of Medicine, KYUSHU UNIVERSITY, Aso. Prof., 医学部・附属病院, 助手 (50284500)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Munetaka Faculty of Medicine, KYUSHU UNIVERSITY, Ass. Prof., 医学部・附属病院, 講師 (10190365)
UENO Hikaru Univ. of Occupational and Environmental Health, KYUSHU UNIVERSITY, Prof., 医学部, 教授 (50260378)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Thrombosis / Gene transfer / TFPI / 血栓予防 |
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| Research Abstract |
A combination of rTFPI irrigation and TFPI gene transfer overcomes the shortcomings shown by each method when used alone and achieves a full coverage of TF activity suppression, thereby enhancing their therapeutic effects without systemic side effects. This combination mya be an effective strategy for the prevention of thrombosis and proliferative changes after angioplasty in humans.
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