2001 Fiscal Year Final Research Report Summary
Brain protection for ischemic insult by the drug induced heat shock protein
| Project/Area Number |
12671382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
SUGA Sadao Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (10171117)
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| Co-Investigator(Kenkyū-buntansha) |
MAYANAGI Keita Keio University, School of Medicine, Instructor, 医学部, 助手 (30286504)
AKAJI Kazunori Institute of Brain and Blood Vessels, Instructor, 脳神経外科, 助手 (90276262)
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| Project Period (FY) |
2000 – 2001
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| Keywords | heat shock protein / cerebral ischemia / tolerance / protection |
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| Research Abstract |
1) Protective effect of GGA for ischemic insult
We used gerbil forebrain ischemic model and rat focal ischemic model.
Although several doses of GGA were introduced to the animals for two weeks before ischemia everyday intraperitoneally, neuronal damage in both global and focal ischemia were not decreased by GGA administration, compared to the control ones. Heat shock protein induction by GGA administration was not presented in gerbil brain.
2) Effect of Hypothermia on the protection for ischemic insult, HSP expression, immediately early gene expression and transcriptional activity
As we could not detect the induction of HSP by the drug, we examined the relationship between protective effect of hypothermia for ischemia and HSP, IEG and AP-1 activity. The results demonstrated that hypothermia had protective effect for ischemia and the increase of Fos expression and AP-1 binding activity by hypothermia. It is suggested that not only HSP but also Fos and AP-1 may correlate to the protective effect of hypothermia for ischemic insults.
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