2001 Fiscal Year Final Research Report Summary
The role of Tumor Necrosis factor in radicular pain
| Project/Area Number |
12671431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
YABUKI Shoji Fukushima Medical University, Department of Orthopaedic Surgery, Assistant Professor, 医学部, 講師 (00260779)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Shinichi Fukushima Medical University, Department of Orthopaedic Surgery, Professor, 医学部, 教授 (80045773)
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| Project Period (FY) |
2000 – 2001
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| Keywords | tumor necrosis factor / radicular pain / disc herniation / compartment syndrome |
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| Research Abstract |
It has been shown using herniated nucleus pulposus model that application of pentoxifylline, an anti-TNF drug, with nucleus pulposus can prevent the increase of endoneurial fluid pressure (EFP) in the rat dorsal root ganglia (DRG) in 2000.
The purpose of the study in 2001 is to clarify whether application of TNF to the nerve root induces abnormal discharges in rat dorsal horn neurons or not, and to clarify the effects of lidocaine which used in nerve root block for treating the radicular pain on the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model.
The results were following; 1) TNF induced abnormal discharges in rat dorsal horn neurons, and 2) lidocaine prevented the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model. The result 1) suggests that TNF plays an important role to induce radicular pain. Also, the result 2) may show a mechanism of the therapeutic effect nerve root block.
In the 2001 studies, it is shown that TNF plays an important role to induce radicular pain, and nerve root block is an useful method for treating the radicular pain.
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