2003 Fiscal Year Final Research Report Summary
Basic research of the gene therapy of testicular tumor cell
| Project/Area Number |
12671537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
KAMANO Hiroshi Kagawa University, Health Center, Prof., 保健管理センター, 教授 (60284337)
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| Project Period (FY) |
2000 – 2003
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| Keywords | A-myb / B-myb |
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| Research Abstract |
The myb family consists of three members, the c-myb protooncogene and myb related genes A-myb and B-myb, all of which encode nuclear sequence-specific DNA-binding protein. C-myb proteins is expressed at high levels in most hematopoietic precursor cells and plays a crucial role in the proliferation and differentiation of these cells.
In the presence of DNA antisense B-myb oligo the proliferation rate of cell was significantly decreased on the fourth day. In the presence of mismatched DNA antisense B-myb oligo the proliferation 'rate of cell was not decreased. In the other hand, in the presence of morpholino antisense B-myb oligo the proliferation rate of cell was significantly decreased. In the presence of mismatched morpholin antisense B-myb oligo the proliferation rate of cell was not decreased.
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