2002 Fiscal Year Final Research Report Summary
The effects of arachidonic acid on urological tumors
| Project/Area Number |
12671544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagasaki University Graduate School of Medical Science |
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Principal Investigator |
KOGA Shigehiko Nagasaki University Graduate School of Medical Science Department of Urology, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (10205354)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Toadyish Nagasaki University Hospital, Department of Pathology, Associate Professor, 医学部附属病院, 助教授 (20253651)
KANDA Shigeru Nagasaki University Graduate School of Medical Science Department of Molecular Microbiology and Immunology, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (20244048)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Arachidonic acid / Cyclooxygenase / Tumors / Renal cell carcinoma |
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| Research Abstract |
We investigated the effects of arachidonic acid on urological tumors.
1. Cyclooxygenase (COX)-2 plays an important role in tumor cell proliferation, resistant to apoptosis, angiogenesis, and invasion in various malignant tumors. Of 131sections of renal cell carcinoma (RCC), 70(53.4%) were positive for COX-2 expression. COX-2 expression was correlated with Ki-67 labeling index, microvessel density, and MMP-2 expression.
2. RCC with sarcomatoid component which has a highly malignant biological behavior. We evaluated 19 sections with sarcomatoid and non-sarcomatoid component. In regard to sarcomatoid component, 15 (78.9%) were positive for COX-2, which showed diffuse staining of tumor cell cytoplasm. In contrast, in regard to non-sarcomatoid component, 8 (42.1%) were positive for COX-2. COX-2 expression was significantly increased in sarcomatoid component compared with non-sarcomatoid component (P=0.02).
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