2001 Fiscal Year Final Research Report Summary
EXPLOITATION OF NEW DIAGNO-THERAPEUTIC PROCEDURES OF HUMAN ENDOCERVICAL ADENOCARCINOMA OF THE UTERUS BASED ON CYTOGENETIC MECHANISMS OF MULTI- STEP CARCINOGENESIS
| Project/Area Number |
12671643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
HIRAI Yasuo CANCER INSTITUTE, DEPT. OF CELL BIOLOGY, ASSOCIATE, 癌研究所・細胞生物部, 研究員 (00260076)
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| Project Period (FY) |
2000 – 2001
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| Keywords | ENDOCERVICAL ADENQCARCINOMAS / TGF 13 RII / BAX / CHROMOSOMAL IMBALANCE / PTEN / MICROSATELLITE INSTABILITY / COMPARATIVE GENOMIC INSTABILITY / MULTISTEP CARCINOGENESIS |
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| Research Abstract |
We analysed the mutational status of the TGF β RII, BAX, and PTEN/MMAC1 genes as well as microsatellite instability (MI) in consecutive cases of endocervical adenocarcinoma of the uterus operated on at our Institute. To examine copy number losses and/or amplifications at the chromosomal region bearing all the genes, we used comparative genornic hybridization (CGH) analysis. CGH analysis may provides a genome-wide overview about tumor-associated genomic imbalances. Among the tumors, a few showed, the MI+ phenotype. Also, few tumors demonstrated a significant mutation with a definite amino acid change in PTEN/MMAC1 gene. CGH analysis demonstrated that a few tumors showed chromosomal copy number losses and/or amplifications, whereas there are no common chromosomal foci showing losses or amplifications among the tumors analysed so far. The role of TGF β RI and BAX genes may be limited as a target gene of MI+ phenotype in endocervical adenocarcinoma, because only a few tumors demonstrated MI+ phenotype in these tumors.
Additional explorations are needed to elucidate the cytogenetic mechanisms of multistep carcinogenesis in endocervical adenocarcinomas of the uterus.
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[Publications] Sekine M, Nagata H, Tsuji S, Hirai Y, Fujimoto S, Hatae M, Kobayashi I, Fujii T, Nagata I, Ushijima K, Obata K, Suzuki M, Yoshinaga M, Umesaki N, Satoh S, Enomoto T, Motoyama S, Tanaka.: "Mutational analysis of BRCA1 and BRCA2 and clinicopathologic analysis of ovarian cancer in 82 ovarian cancer families : two common founder mutations of BRCA1 in Japanese population"Clin Cancer Res.. 7(10). 3144-50 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sekine M, Nagata H, Tsuji S, Hirai Y, Fujimoto S, Hatae M, Kobayashi I, Fujii T, Nagata I, Ushijima K, Obata K, Suzuki M, Yoshinaga M, Umesaki N, Satoh S, Enomoto T, Motoyama S, Tanaka K.: "Localization of a novel susceptibility gene for familial ovarian cencer to chromosome 3p22-p25"Hum Mol Genet.. 10(13). 1421-9 (2001)
Description
「研究成果報告書概要(欧文)」より
