2001 Fiscal Year Final Research Report Summary
Investigation on the pathogenesis of acute peripheral facial palsy caused by herpes simplex virus reactivation.
| Project/Area Number |
12671644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
FURUWA Yasushi Hokkaido Univ., Grad. School of Med., Asso. Prof., 大学院・医学研究科, 助教授 (60261301)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Hirofumi Hokkaido Univ., Grad. School of Med., Asso. Prof., 大学院・医学研究科, 助教授 (30292006)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Herpes simplex virus / Varicella-zoster virus / Tumor necrosis factor-α / Antiviral drug / MRI / Anti-ganglioside antibodies / Peripheral facial palsy |
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| Research Abstract |
1. Anti-HSV antibody in patients with peripheral facial palsy.
The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation. VZV reactivation causes acute peripheral facial palsy in most patients who lack antibodies to HSV.
2. Herpes virus reactivation and serum tumor necrosis factor-α levels in atients with acute peripheral facial palsy.
Tumor necrosis factor-α(TNF-α) plays an important role in several inflammatory and infectious diseases. We evaluated serum TNF-α levels of 75 patients with acute peripheral facial palsy. The results indicate that serum TNF-α levels are not affected by HSV-1 or VZV reactivation in patients with facial palsy.
3. Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy.
We sought to determine the efficacy acyclovir-prednisone therapy for patients with HSV-1 reactivation. The results suggest that early diagnosis of HSV-1 reactivation by PCR and subsequent acyclovir-prednisone therapy do not improve recovery from facial palsy.
4. Detection of the anti-ganglioside antibodies in patients with acute peripheral facial palsy.
We examined 26 sera of the patients with history of over two episodes of acute facial nerve palsy for anti-ganglioside antibodtes. We detected anti-Ga1NAc-Gd1a-GD1a IgG antibody from 2 sera by ELISA method. No anti-ganglioside antibodes were detected by TLC. It is suggested that the anti-ganglioside antibody is not main pathogenesis of acute peripheral facial nerve palsy.
5. Herpes virus reactivation and gadolinium-enhanced magnetic resonance imaging in patients with facial palsy.
We studied 15 patients with acute peripheral facial palsy to compare virologic tests and gadolinium-enhanced MRI findings. The results suggest that the meatal fundus or the geniculate ganglion may be affected first by virus reactivation in patients with herpetic facial palsy.
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