2001 Fiscal Year Final Research Report Summary
The role of the nigrostriatal dopaminergic pathway in the sequential progress
| Project/Area Number |
12671805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
MASUDA Yuji Graduate School of Dentistry, Osaka University, Assistant Professor, 大学院・歯学研究科, 講師 (20190366)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Tomio Syowa University Faculty of Dentistry, Osaka University, Professor, 歯学部, 教授 (70184760)
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| Project Period (FY) |
2000 – 2001
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| Keywords | microdialysis / mastication / putamen / dopamine / 6OHDA / intake behavior |
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| Research Abstract |
The masticatory sequence is a whole set of movements from ingestion to swallowing. The masticatory sequence could be divided into three recognized stages (stage I, IIa, IIb) in the rabbit based on the form of jaw movements. It is, however, still unclear which neural mechanism is involved in the transition of the masticatory stages. The aim of this project was to clarify the role of the nigrostriatal dopaminergic pathway in the sequential progress during mastication.
We obtained the findings in this study as follows ;
1. We examined the alteration of dopamine (DA) concentration in the extracellular space of the putamen during 5 consecutive minutes of mastication in the awake rabbit, using the microdialysis. Analysis of the microdialysate samples indicated that the DA concentration in the putamen increased significantly during mastication, compared with resting the period.
2. We studied the effect of bilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal dopaminergic pathway on feeding behavior in freely-moving rabbits by means of video and electromyogram (EMG) of masticatory muscles. We observed that the duration of intake behavior, in which the rabbit inserted its mouth into the pellet-box and seemed to pick up pellets, was shortened after the lesions. Further, the number of intake behaviors for consuming 1 g of pellets was increased. During intake behavior, masseteric EMG activities varied in the control rabbits, whereas this variation was smaller in the lesioned subjects. This suggests that the behaviors of picking up the pellets and chewing them were intermingled during intake behavior in the control subjects. This effect was observed only when the dopaminergic pathway from the substantia nigra to the ventral part of the putamen was interrupted, and not when the dorsal part was disrupted.
These results suggested that the nigrostriatal dopaminergic pathway might play a role in the sequential progress during mastication.
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[Publications] Masuda, Y., Kato. T., Hidaka, O., Matsuo, R., Inoue, T., Iwata, K. and Morimoto, T.: "Neuronal activity in the putamen and the globus pallidus or rabbit during mastication"Neurosci. Res.. 39. 11-20 (2001)
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[Publications] Komuro, A., Masuda, Y., Iwata, K., Kobayashi, M., Kato, T., Hidaka, O. and Morimoto, T.: "Influence of food thickness and hardness on possible feed-forward control of the masseteric muscle activity in the anesthetized rabbit"Neurosci. Res.. 39. 21-29 (2001)
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[Publications] Komuro, A., Morimoto, T., Iwata, K., Inoue, T., Masuda, Y., Kato. T. and Hidaka, O.: "Putative feed-forward control of jaw-closing muscle activity during rhythmic jaw movements in the anesthetized rabbit"J. Neurophysiol. 86. 2834-2884 (2001)
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[Publications] Iwata, K., Imai, T., Tsuboi, Y., Tashiro, A., Ogawa, A., Morimoto, T., Masuda, Y., Tachibana, Y. and Hu, J: "Alteration of medullary dorsal Horn neuronal activity following interior alveolar nerve transection in rats"J. Neurophysiol. 86. 2868-2877 (2001)
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[Publications] Kobayashi, M., Masuda, Y., Fujimoto, Y., Matsuya, T., Yamamura, K., Yamada, Y., Maeda, N. and Morimoto, T.: "Electrophysiological analysis of rhythmic jaw movements in the freely-moving mouse"Physiol. Behav.. 75. 377-385 (2002)
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[Publications] Iwata, K., Fukuoka, T., Kondo, E., Tsuboi, Y., Tashiro. A., Noguchi, K., Masuda, Y., Morimoto, T. and Kanda, K.: "Plastic changes in nociceptive transmission of the rat spinal cord with advancing age"J. Neurophysiol. 87. 1086-1093 (2002)
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[Publications] Narita, N., Yamamura, K., Yao, D. Y., Martin, R., Masuda, Y. and Sessle, B. J.: "Effects of reversible bilateral inactivation of primate lateral pericentral cortex on mastication"Arch. Oral Biol. (in press). (2002)
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[Publications] Yamamura, K., Narita, N., Yao, D. Y., Martin, R., Masuda, Y. and Sessle, B. J.: "Effects of reversible inactivation of bilateral face primary motor cortex on mastication and swallowing"Brain Res.. (in press). (2002)
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