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2001 Fiscal Year Final Research Report Summary

Angiotensin II is a neurotransmitter in submandibular ganglion

Research Project

Project/Area Number 12671816
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

SUZUKI Takashi  Tokyo Dental College, Department of Dentistry, Professor, 歯学部, 教授 (10064669)

Project Period (FY) 2000 – 2001
KeywordsHamster / Submandibular ganglion / Angiotensin II / Calcium channel / Calcium current / GTP-binding protein / Protein kinase C / Losartan
Research Abstract

Angiotensin II(AngII)is one of the most important vasoconstrictive hormones but is also known to act as a neuromodulator and a neurotransmitter in the central and peripheral nervous system. In a previous study, we have shown that AngII, mediated by AT, receptors, inhibits voltage-dependent calcium channels (VDCCs) currents (Ica) via G-proteins in submandibular ganglion (SMG) neurons. In this study, we further characterized the signal transduction of AngII-induced inhibition of Ica. Application of 1uM AngII inhibited Ica by 32.1%. Intracellular dialysis of anti-Gq/11 antibodies attenuated these inhibition. In addition, treatment of protein kinase G (PKC) activator and inhibitor also attenuated the inhibition. I therefore conclude that Ang II inhibits VDCCs via Gq/11-proteins involving in SMG neurons. In addition, such PKC-dependent pathways mediated mainly L-type VDCCs inhibition.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] H.Ikegami, T.Yamada, T.Suzuki: "AngiotensinII-induced depolarizations in hamster submandibular ganglion neurons"Bulletin of Tokyo Dental College. 42(2). 29-34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ikegami, T.Endoh, T.Suzuki: "Angiotensin, II -induced inhibition of calcium currents in hamster submandibular ganglion neurons"Neuroscience Research. 41. 227-232 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Ikegami, T. Yamada, T. Suzuki.: "Angiotensin II-induced depolarizations in hamster submandibular ganglion neruons."Bulletin of Tokyo Dental College. 42(2). 29-34 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ikegami, T. Endoh, T. Suzuki.: "Angiotensin II-induced inhibition of calcium currents in hamster submandibular ganglion neurons."Neuroscience Research. 417. 227-232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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