2001 Fiscal Year Final Research Report Summary
Search for New Natural Products from Unutilized North Line Plant Biomass
| Project/Area Number |
12672045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MORITA Hiroshi Hokkaido Univ., Grad. School of Pharm. Sci., Associate Prof., 大学院・薬学研究科, 助教授 (70220069)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Daphniphyllum humile / Celosia argentea / Cephalotaxus harringtonia var. nana / Lycopodium serratum var. serratum / Lycopodium complanatum / Lycopodium chinense / alkaloid / cyclic peptide |
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| Research Abstract |
During our search for new natural products from unutilized north line plant biomass, unique alkaloids and peptides have been isolated from Daphniphyllum humile, Cephalotaxus harringtonia var. nana, Lycopodium serratum var. serratum, L complanatum, L. chinense, and Celosia argentea. These nitrogen-containing compounds possessed unique chemical structures and some of them exhibited unique biological activities such as antimitotic, antitumor, and antimalaria activities. From biogenetic points of view, these alkaloids were interesting and we proposed plausible biogenetic paths.
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