2001 Fiscal Year Final Research Report Summary
Studies on controlled biodistribution of submicron-sized drug-carriers with surface modification and its controlling mechanism
| Project/Area Number |
12672091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
TALEUCHI Hirofumi Gifu Pharmaceutical University, Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (50171616)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiromitsu Gifu Pharmaceutical University, Pharmaceutical Sciences, Research Associate, 薬学部, 助手 (30275094)
KAWASHIMA Yoshiaki Gifu Pharmaceutical University, Pharmaceutical Sciences, Professor, 薬学部, 教授 (30082978)
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| Project Period (FY) |
2000 – 2001
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| Keywords | surface modification / liposome / nanosphere / mires adhesion / Targeting / cancer cell |
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| Research Abstract |
1. Mucoadhesive property of chitosan-coated liposomes (CS-Lip) was much improved by reducing their size to sub-micron. Penetration of the submicron-sized CS-Lip into the mucous layer of rat intestine was observed by using a con focal laser scanning microscope. Enteral absorption of a peptide drug, calcitonin, was enhanced by use of the submicron-sized CS-Lip as a drug carrier in rats. The resultant pharmacological effect was prolonged up to 48 hr.
2. Circulation of liposomes after intravenous injection was prolonged by coating the surface of liposomes with polymers. The correlation between the property of polymers and the circulating property was clarified. The similar improved circulation was observed for the polymer-coated lipid nanospheres. Targeting efficiency of the polymer-coated liposomes- was calculated in tumor bearing rats. The results suggested that the affinity of liposomes to the cancer cell was increased by polymer coating.
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