• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2001 Fiscal Year Final Research Report Summary

Pharmaceutical activity of ubiquinone analogs

Research Project

Project/Area Number 12672164
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 医薬分子機能学
Research InstitutionKobe Gakuin University

Principal Investigator

MORI Koichi  Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 教授 (20098487)

Co-Investigator(Kenkyū-buntansha) TAKUMA Kazuhiro  Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助手 (90289025)
Project Period (FY) 2000 – 2001
Keywordsubiquinone / ubiquinone analog / antioxidant / lipid peroxidation / free radical / mitochondira
Research Abstract

New alkyl-l, 4-naphthoquinone, and alkylthio- or arylthio-2, 6-dimethyl-l, 4-benzoquinone as ubiquinone analog were synthesized and tested for the effect on the respiratory chain system and lipid peroxidation in bovine heart mitochondria (BHM). These quinones showed weak inhibitory activities on the respiratory system in BHM. The several compounds of these quinones were efficient as exogenous ubiquinone-10 for the inhibition of lipid peroxidation. The chemical reactivity toward peroxy radicals was investigated in n-hexane, and assessed by in the competition with N, N'-diphenyl-p-phenylenediamine and their antioxidant potency was evaluated in the oxidation of methyl linoleate in hexane. The potency was assessed by the extent of the reduction in the rate of oxidation and duration of inhibition period.

URL: 

Published: 2003-09-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi