Pharmaceutical activity of ubiquinone analogs

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 12672164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 医薬分子機能学
• Research Institution: Kobe Gakuin University
• Principal Investigator: MORI Koichi Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 教授 (20098487)
• Co-Investigator(Kenkyū-buntansha): TAKUMA Kazuhiro Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助手 (90289025)
• Project Period (FY): 2000 – 2001
• Keywords: ubiquinone / ubiquinone analog / antioxidant / lipid peroxidation / free radical / mitochondira

Research Abstract

New alkyl-l, 4-naphthoquinone, and alkylthio- or arylthio-2, 6-dimethyl-l, 4-benzoquinone as ubiquinone analog were synthesized and tested for the effect on the respiratory chain system and lipid peroxidation in bovine heart mitochondria (BHM). These quinones showed weak inhibitory activities on the respiratory system in BHM. The several compounds of these quinones were efficient as exogenous ubiquinone-10 for the inhibition of lipid peroxidation. The chemical reactivity toward peroxy radicals was investigated in n-hexane, and assessed by in the competition with N, N'-diphenyl-p-phenylenediamine and their antioxidant potency was evaluated in the oxidation of methyl linoleate in hexane. The potency was assessed by the extent of the reduction in the rate of oxidation and duration of inhibition period.